Altered Ca(2+) Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis

Over 95% of Polycythemia Vera (PV) patients carry the V617F mutation in the tyrosine kinase Janus kinase 2 (JAK2), resulting in uncontrolled erythroid proliferation and a high risk of thrombosis. Using mass spectrometry, we analyzed the RBC membrane proteome and showed elevated levels of multiple Ca...

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Detalles Bibliográficos
Autores principales: Buks, Ralfs, Dagher, Tracy, Rotordam, Maria Giustina, Monedero Alonso, David, Cochet, Sylvie, Gautier, Emilie-Fleur, Chafey, Philippe, Cassinat, Bruno, Kiladjian, Jean-Jacques, Becker, Nadine, Plo, Isabelle, Egée, Stéphane, El Nemer, Wassim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750512/
https://www.ncbi.nlm.nih.gov/pubmed/35011611
http://dx.doi.org/10.3390/cells11010049

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