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Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure

Skin is one of the main targets of the outdoor stressors. Considering that pollution levels are rising progressively, it is not surprising that several cutaneous conditions have been associated with its exposure. Among the pollutants, diesel engine exhaust (DEE) represents one of the most toxic, as...

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Autores principales: Pambianchi, Erika, Ferrara, Francesca, Pecorelli, Alessandra, Benedusi, Mascia, Choudhary, Hina, Therrien, Jean-Philippe, Valacchi, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750544/
https://www.ncbi.nlm.nih.gov/pubmed/34943031
http://dx.doi.org/10.3390/antiox10121928
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author Pambianchi, Erika
Ferrara, Francesca
Pecorelli, Alessandra
Benedusi, Mascia
Choudhary, Hina
Therrien, Jean-Philippe
Valacchi, Giuseppe
author_facet Pambianchi, Erika
Ferrara, Francesca
Pecorelli, Alessandra
Benedusi, Mascia
Choudhary, Hina
Therrien, Jean-Philippe
Valacchi, Giuseppe
author_sort Pambianchi, Erika
collection PubMed
description Skin is one of the main targets of the outdoor stressors. Considering that pollution levels are rising progressively, it is not surprising that several cutaneous conditions have been associated with its exposure. Among the pollutants, diesel engine exhaust (DEE) represents one of the most toxic, as it is composed of a mixture of many different noxious chemicals generated during the compression cycle, for ignition rather than an electrical spark as in gasoline engines. The toxic chemicals of most concern in DEE, besides the oxides of nitrogen, sulfur dioxide and various hydrocarbons, are metals that can induce oxidative stress and inflammation. The present study aimed to evaluate the effects of topical application, singularly or in combination, of the iron-chelator deferoxamine and a commercially available formulation, CE Ferulic, in up to 4-day DEE-exposed skin. DEE induced a significant increase in the oxidative marker 4-hydroxy-nonenal (4HNE) and matrix-metallopeptidase-9 (MMP-9), the loss of cutaneous-barrier-associated proteins (filaggrin and involucrin) and a decrease in collagen-1, while the formulations prevented the cutaneous damage in an additive manner. In conclusion, this study suggests that iron plays a key role in DEE-induced skin damage and its chelation could be an adjuvant strategy to reinforce antioxidant topical formulations.
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spelling pubmed-87505442022-01-12 Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure Pambianchi, Erika Ferrara, Francesca Pecorelli, Alessandra Benedusi, Mascia Choudhary, Hina Therrien, Jean-Philippe Valacchi, Giuseppe Antioxidants (Basel) Article Skin is one of the main targets of the outdoor stressors. Considering that pollution levels are rising progressively, it is not surprising that several cutaneous conditions have been associated with its exposure. Among the pollutants, diesel engine exhaust (DEE) represents one of the most toxic, as it is composed of a mixture of many different noxious chemicals generated during the compression cycle, for ignition rather than an electrical spark as in gasoline engines. The toxic chemicals of most concern in DEE, besides the oxides of nitrogen, sulfur dioxide and various hydrocarbons, are metals that can induce oxidative stress and inflammation. The present study aimed to evaluate the effects of topical application, singularly or in combination, of the iron-chelator deferoxamine and a commercially available formulation, CE Ferulic, in up to 4-day DEE-exposed skin. DEE induced a significant increase in the oxidative marker 4-hydroxy-nonenal (4HNE) and matrix-metallopeptidase-9 (MMP-9), the loss of cutaneous-barrier-associated proteins (filaggrin and involucrin) and a decrease in collagen-1, while the formulations prevented the cutaneous damage in an additive manner. In conclusion, this study suggests that iron plays a key role in DEE-induced skin damage and its chelation could be an adjuvant strategy to reinforce antioxidant topical formulations. MDPI 2021-11-30 /pmc/articles/PMC8750544/ /pubmed/34943031 http://dx.doi.org/10.3390/antiox10121928 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pambianchi, Erika
Ferrara, Francesca
Pecorelli, Alessandra
Benedusi, Mascia
Choudhary, Hina
Therrien, Jean-Philippe
Valacchi, Giuseppe
Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure
title Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure
title_full Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure
title_fullStr Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure
title_full_unstemmed Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure
title_short Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure
title_sort deferoxamine treatment improves antioxidant cosmeceutical formulation protection against cutaneous diesel engine exhaust exposure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750544/
https://www.ncbi.nlm.nih.gov/pubmed/34943031
http://dx.doi.org/10.3390/antiox10121928
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