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Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits

Wound healing consists of several continuous phases involving various cells and chemical intermediates. As a rich source of nutrition elements, honey has proved to have potential benefits in the treatment of various diseases. The present study was designed to investigate the healing effect of a hone...

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Autores principales: Mekkaoui, Mouna, Assaggaf, Hamza, Qasem, Ahmed, El-Shemi, Adel, Abdallah, Emad M., Bouidida, El Houcine, Naceiri Mrabti, Hanae, Cherrah, Yahya, Alaoui, Katim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750595/
https://www.ncbi.nlm.nih.gov/pubmed/35010154
http://dx.doi.org/10.3390/foods11010028
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author Mekkaoui, Mouna
Assaggaf, Hamza
Qasem, Ahmed
El-Shemi, Adel
Abdallah, Emad M.
Bouidida, El Houcine
Naceiri Mrabti, Hanae
Cherrah, Yahya
Alaoui, Katim
author_facet Mekkaoui, Mouna
Assaggaf, Hamza
Qasem, Ahmed
El-Shemi, Adel
Abdallah, Emad M.
Bouidida, El Houcine
Naceiri Mrabti, Hanae
Cherrah, Yahya
Alaoui, Katim
author_sort Mekkaoui, Mouna
collection PubMed
description Wound healing consists of several continuous phases involving various cells and chemical intermediates. As a rich source of nutrition elements, honey has proved to have potential benefits in the treatment of various diseases. The present study was designed to investigate the healing effect of a honey mixture with selected essential oils on chemical and thermal wound models in rabbits. Dressing mixtures of Thymus vulgaris honey with three essential oils (Origanum vulgare, Rosmarinus officinalis, and Thymus vulgaris) were prepared and applied daily in the treatment groups. These essential oils were rich in phytochemicals and had significant antibacterial activity against four selected ATCC bacterial strains. Madecasol ointment was used as a standard control. The healing effect of the mixtures was evaluated by measuring wound surface area and comparing healing time. The results showed that the healing rate in the treatment groups was significantly higher than that of the untreated group and standard group. The best healing effect for burns was seen in the mixture of honey and Thymus vulgaris essential oil, which had wound closure rates of 85.21% and 82.14% in thermal- and chemical-induced burns, respectively, and showed the shortest healing time (14 days) in comparison to other groups. Therefore, it can be concluded that honey mixtures have significant beneficial effects on skin wound healing and, thus, they may be used as a healing agent in different types of wounds in humans after specific clinical trials.
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spelling pubmed-87505952022-01-12 Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits Mekkaoui, Mouna Assaggaf, Hamza Qasem, Ahmed El-Shemi, Adel Abdallah, Emad M. Bouidida, El Houcine Naceiri Mrabti, Hanae Cherrah, Yahya Alaoui, Katim Foods Article Wound healing consists of several continuous phases involving various cells and chemical intermediates. As a rich source of nutrition elements, honey has proved to have potential benefits in the treatment of various diseases. The present study was designed to investigate the healing effect of a honey mixture with selected essential oils on chemical and thermal wound models in rabbits. Dressing mixtures of Thymus vulgaris honey with three essential oils (Origanum vulgare, Rosmarinus officinalis, and Thymus vulgaris) were prepared and applied daily in the treatment groups. These essential oils were rich in phytochemicals and had significant antibacterial activity against four selected ATCC bacterial strains. Madecasol ointment was used as a standard control. The healing effect of the mixtures was evaluated by measuring wound surface area and comparing healing time. The results showed that the healing rate in the treatment groups was significantly higher than that of the untreated group and standard group. The best healing effect for burns was seen in the mixture of honey and Thymus vulgaris essential oil, which had wound closure rates of 85.21% and 82.14% in thermal- and chemical-induced burns, respectively, and showed the shortest healing time (14 days) in comparison to other groups. Therefore, it can be concluded that honey mixtures have significant beneficial effects on skin wound healing and, thus, they may be used as a healing agent in different types of wounds in humans after specific clinical trials. MDPI 2021-12-23 /pmc/articles/PMC8750595/ /pubmed/35010154 http://dx.doi.org/10.3390/foods11010028 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mekkaoui, Mouna
Assaggaf, Hamza
Qasem, Ahmed
El-Shemi, Adel
Abdallah, Emad M.
Bouidida, El Houcine
Naceiri Mrabti, Hanae
Cherrah, Yahya
Alaoui, Katim
Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits
title Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits
title_full Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits
title_fullStr Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits
title_full_unstemmed Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits
title_short Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits
title_sort ethnopharmacological survey and comparative study of the healing activity of moroccan thyme honey and its mixture with selected essential oils on two types of wounds on albino rabbits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750595/
https://www.ncbi.nlm.nih.gov/pubmed/35010154
http://dx.doi.org/10.3390/foods11010028
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