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Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression
Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the host epigenome and as such can impact disease progression, as well as the molecular processes...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750639/ https://www.ncbi.nlm.nih.gov/pubmed/35016709 http://dx.doi.org/10.1186/s13148-022-01230-w |
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author | Titanji, Boghuma K. Gwinn, Marta Marconi, Vincent C. Sun, Yan V. |
author_facet | Titanji, Boghuma K. Gwinn, Marta Marconi, Vincent C. Sun, Yan V. |
author_sort | Titanji, Boghuma K. |
collection | PubMed |
description | Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the host epigenome and as such can impact disease progression, as well as the molecular processes driving non-AIDS comorbidities in PWH. Epigenetic epidemiologic studies including epigenome-wide association studies (EWAS) offer a unique set of tools to expand our understanding of HIV disease and to identify novel strategies applicable to treatment and diagnosis in this patient population. In this review, we summarize the current state of knowledge from epigenetic epidemiologic studies of PWH, identify the main challenges of this approach, and highlight future directions for the field. Emerging epigenetic epidemiologic studies of PWH can expand our understanding of HIV infection and health outcomes, improve scientific validity through collaboration and replication, and increase the coverage of diverse populations affected by the global HIV pandemic. Through this review, we hope to highlight the potential of EWAS as a tool for HIV research and to engage more investigators to explore its application to important research questions. |
format | Online Article Text |
id | pubmed-8750639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-87506392022-01-11 Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression Titanji, Boghuma K. Gwinn, Marta Marconi, Vincent C. Sun, Yan V. Clin Epigenetics Review Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the host epigenome and as such can impact disease progression, as well as the molecular processes driving non-AIDS comorbidities in PWH. Epigenetic epidemiologic studies including epigenome-wide association studies (EWAS) offer a unique set of tools to expand our understanding of HIV disease and to identify novel strategies applicable to treatment and diagnosis in this patient population. In this review, we summarize the current state of knowledge from epigenetic epidemiologic studies of PWH, identify the main challenges of this approach, and highlight future directions for the field. Emerging epigenetic epidemiologic studies of PWH can expand our understanding of HIV infection and health outcomes, improve scientific validity through collaboration and replication, and increase the coverage of diverse populations affected by the global HIV pandemic. Through this review, we hope to highlight the potential of EWAS as a tool for HIV research and to engage more investigators to explore its application to important research questions. BioMed Central 2022-01-11 /pmc/articles/PMC8750639/ /pubmed/35016709 http://dx.doi.org/10.1186/s13148-022-01230-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Titanji, Boghuma K. Gwinn, Marta Marconi, Vincent C. Sun, Yan V. Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression |
title | Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression |
title_full | Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression |
title_fullStr | Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression |
title_full_unstemmed | Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression |
title_short | Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression |
title_sort | epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750639/ https://www.ncbi.nlm.nih.gov/pubmed/35016709 http://dx.doi.org/10.1186/s13148-022-01230-w |
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