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Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression

Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the host epigenome and as such can impact disease progression, as well as the molecular processes...

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Autores principales: Titanji, Boghuma K., Gwinn, Marta, Marconi, Vincent C., Sun, Yan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750639/
https://www.ncbi.nlm.nih.gov/pubmed/35016709
http://dx.doi.org/10.1186/s13148-022-01230-w
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author Titanji, Boghuma K.
Gwinn, Marta
Marconi, Vincent C.
Sun, Yan V.
author_facet Titanji, Boghuma K.
Gwinn, Marta
Marconi, Vincent C.
Sun, Yan V.
author_sort Titanji, Boghuma K.
collection PubMed
description Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the host epigenome and as such can impact disease progression, as well as the molecular processes driving non-AIDS comorbidities in PWH. Epigenetic epidemiologic studies including epigenome-wide association studies (EWAS) offer a unique set of tools to expand our understanding of HIV disease and to identify novel strategies applicable to treatment and diagnosis in this patient population. In this review, we summarize the current state of knowledge from epigenetic epidemiologic studies of PWH, identify the main challenges of this approach, and highlight future directions for the field. Emerging epigenetic epidemiologic studies of PWH can expand our understanding of HIV infection and health outcomes, improve scientific validity through collaboration and replication, and increase the coverage of diverse populations affected by the global HIV pandemic. Through this review, we hope to highlight the potential of EWAS as a tool for HIV research and to engage more investigators to explore its application to important research questions.
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spelling pubmed-87506392022-01-11 Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression Titanji, Boghuma K. Gwinn, Marta Marconi, Vincent C. Sun, Yan V. Clin Epigenetics Review Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the host epigenome and as such can impact disease progression, as well as the molecular processes driving non-AIDS comorbidities in PWH. Epigenetic epidemiologic studies including epigenome-wide association studies (EWAS) offer a unique set of tools to expand our understanding of HIV disease and to identify novel strategies applicable to treatment and diagnosis in this patient population. In this review, we summarize the current state of knowledge from epigenetic epidemiologic studies of PWH, identify the main challenges of this approach, and highlight future directions for the field. Emerging epigenetic epidemiologic studies of PWH can expand our understanding of HIV infection and health outcomes, improve scientific validity through collaboration and replication, and increase the coverage of diverse populations affected by the global HIV pandemic. Through this review, we hope to highlight the potential of EWAS as a tool for HIV research and to engage more investigators to explore its application to important research questions. BioMed Central 2022-01-11 /pmc/articles/PMC8750639/ /pubmed/35016709 http://dx.doi.org/10.1186/s13148-022-01230-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Titanji, Boghuma K.
Gwinn, Marta
Marconi, Vincent C.
Sun, Yan V.
Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression
title Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression
title_full Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression
title_fullStr Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression
title_full_unstemmed Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression
title_short Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression
title_sort epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750639/
https://www.ncbi.nlm.nih.gov/pubmed/35016709
http://dx.doi.org/10.1186/s13148-022-01230-w
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