SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

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SARS-CoV-2 non-structural protein Nsp14 is a highly conserved enzyme necessary for viral replication. Nsp14 forms a stable complex with non-structural protein Nsp10 and exhibits exoribonuclease and N7-methyltransferase activities. Protein-interactome studies identified human sirtuin 5 (SIRT5) as a p...

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Detalles Bibliográficos
Autores principales: Walter, Marius, Chen, Irene P, Vallejo-Gracia, Albert, Kim, Ik-Jung, Bielska, Olga, Lam, Victor L, Hayashi, Jennifer M, Cruz, Andrew, Shah, Samah, Gross, John D, Krogan, Nevan J, Schilling, Birgit, Ott, Melanie, Verdin, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750649/
https://www.ncbi.nlm.nih.gov/pubmed/35018374
http://dx.doi.org/10.1101/2022.01.04.474979
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