Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human and murine β-coronaviruses. The potency of in-cell CSNK2A target engagement across the set of inhibitors correlated with antiviral activi...

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Detalles Bibliográficos
Autores principales: Yang, Xuan, Dickmander, Rebekah J., Bayati, Armin, Taft-Benz, Sharon A., Smith, Jeffery L., Wells, Carrow I., Madden, Emily A., Brown, Jason W., Lenarcic, Erik M., Yount, Boyd L., Chang, Edcon, Axtman, Alison D., Baric, Ralph S., Heise, Mark T., McPherson, Peter S., Moorman, Nathaniel J., Willson, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750650/
https://www.ncbi.nlm.nih.gov/pubmed/35018375
http://dx.doi.org/10.1101/2022.01.03.474779

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