Older adults mount less durable humoral responses to two doses of COVID-19 mRNA vaccine, but strong initial responses to a third dose

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BACKGROUND: Third COVID-19 vaccine doses are broadly recommended, but immunogenicity data remain limited, particularly in older adults. METHODS: We measured circulating antibodies against the SARS-CoV-2 spike protein receptor-binding domain, ACE2 displacement, and virus neutralization against ancest...

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Detalles Bibliográficos
Autores principales: Mwimanzi, Francis, Lapointe, Hope R., Cheung, Peter K., Sang, Yurou, Yaseen, Fatima, Umviligihozo, Gisele, Kalikawe, Rebecca, Datwani, Sneha, Omondi, F. Harrison, Burns, Laura, Young, Landon, Leung, Victor, Agafitei, Olga, Ennis, Siobhan, Dong, Winnie, Basra, Simran, Lim, Li Yi, Ng, Kurtis, Pantophlet, Ralph, Brumme, Chanson J., Montaner, Julio S.G., Prystajecky, Natalie, Lowe, Christopher F., DeMarco, Mari L., Holmes, Daniel T., Simons, Janet, Niikura, Masahiro, Romney, Marc G., Brumme, Zabrina L., Brockman, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750654/
https://www.ncbi.nlm.nih.gov/pubmed/35018381
http://dx.doi.org/10.1101/2022.01.06.22268745
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