Cargando…

LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease with a similar clinical presentation and progression to idiopathic Parkinson’s disease, and common variation is linked to disease risk. Recapitulation of the genotype in rodent models causes abnormal dopamine release and inc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Skelton, Patrick D., Tokars, Valerie, Parisiadou, Loukia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750662/ https://www.ncbi.nlm.nih.gov/pubmed/35011731 http://dx.doi.org/10.3390/cells11010169

Ejemplares similares

Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations
por: Chen, Chuyu, et al.
Publicado: (2020)

R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
por: Xenias, Harry S., et al.
Publicado: (2022)

Tissue specific LRRK2 interactomes reveal a distinct striatal functional unit
por: Zhao, Yibo, et al.
Publicado: (2023)

A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2
por: Kuhlmann, Naila, et al.
Publicado: (2020)

Synapse-specific opioid modulation of thalamo-cortico-striatal circuits
por: Birdsong, William T, et al.
Publicado: (2019)

Autism as a disease of the synapse: search for mechanistic insight
por: Ehrenreich, Hannelore
Publicado: (2015)

Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2
por: Vlachakis, Dimitrios, et al.
Publicado: (2018)

Origins of Parkinson’s Disease in Brain Development: Insights From Early and Persistent Effects of LRRK2-G2019S on Striatal Circuits
por: Huntley, George W., et al.
Publicado: (2020)

Leucine‐rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes
por: Mercatelli, Daniela, et al.
Publicado: (2019)

Neuroglial Plasticity at Striatal Glutamatergic Synapses in Parkinson's Disease
por: Villalba, Rosa M., et al.
Publicado: (2011)

Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?
por: Charron, Giselle, et al.
Publicado: (2014)

Striatal Synapse Degeneration and Dysfunction Are Reversed by Reactivation of Wnt Signaling
por: Galli, Soledad, et al.
Publicado: (2021)

Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice
por: Giesert, Florian, et al.
Publicado: (2013)

Neuronal Firing and Glutamatergic Synapses in the Substantia Nigra Pars Reticulata of LRRK2-G2019S Mice
por: Sitzia, Giacomo, et al.
Publicado: (2022)

Cell-Type-Specific Neuroproteomics of Synapses
por: Yim, Yun Young, et al.
Publicado: (2023)

Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses
por: Fukaya, Ryota, et al.
Publicado: (2023)

Excitatory transmission at thalamo–striatal synapses mediates susceptibility to social stress
por: Christoffel, Daniel J., et al.
Publicado: (2015)

The LRRK2 signalling system
por: Price, Alice, et al.
Publicado: (2018)

Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2
por: Nazish, Iqra, et al.
Publicado: (2023)

Air Pollution and Type 2 Diabetes: Mechanistic Insights
por: Rajagopalan, Sanjay, et al.
Publicado: (2012)

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
por: Taymans, Jean-Marc, et al.
Publicado: (2011)

Dynamic and redundant regulation of LRRK2 and LRRK1 expression
por: Biskup, Saskia, et al.
Publicado: (2007)

‘Up with the LRRK’: a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement
por: Eyers, Patrick A.
Publicado: (2016)

The emerging role of LRRK2 in tauopathies
por: Herbst, Susanne, et al.
Publicado: (2022)

LRRK2: Cause, Risk, and Mechanism
por: Paisán-Ruiz, Coro, et al.
Publicado: (2013)

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
por: Malik, Asad U., et al.
Publicado: (2021)

Computational analysis of the LRRK2 interactome
por: Manzoni, Claudia, et al.
Publicado: (2015)

Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation
por: Fasiczka, Rachel, et al.
Publicado: (2023)

Capturing the domain crosstalk in full length LRRK2 and LRRK2(RCKW)
por: Störmer, Eliza, et al.
Publicado: (2023)

Impact of Type II LRRK2 inhibitors on signaling and mitophagy
por: Tasegian, Anna, et al.
Publicado: (2021)

Assaying the Kinase Activity of LRRK2 in vitro
por: Lewis, Patrick A.
Publicado: (2012)

Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization
por: De Wit, T., et al.
Publicado: (2018)

LRRK2 and Protein Aggregation in Parkinson’s Disease: Insights From Animal Models
por: Dues, Dylan J., et al.
Publicado: (2020)

Guilt-by-Association – Functional Insights Gained From Studying the LRRK2 Interactome
por: Gloeckner, Christian Johannes, et al.
Publicado: (2020)

Structural Insights and Development of LRRK2 Inhibitors for Parkinson’s Disease in the Last Decade
por: Thakur, Gunjan, et al.
Publicado: (2022)

In vivo overexpression of synaptogyrin‐3 promotes striatal synaptic dopamine uptake in LRRK2(R1441G) mutant mouse model of Parkinson's disease
por: Ho, Philip Wing‐Lok, et al.
Publicado: (2023)

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation
por: Lobbestael, E., et al.
Publicado: (2016)

Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers
por: Wang, Shijie, et al.
Publicado: (2017)

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice
por: Beccano-Kelly, Dayne A., et al.
Publicado: (2014)

Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis
por: Lewis, Patrick A.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0da6ogtf4hhog7u5kmhha6shha