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Covering the Role of PGC-1α in the Nervous System

The peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a well-known transcriptional coactivator involved in mitochondrial biogenesis. PGC-1α is implicated in the pathophysiology of many neurodegenerative disorders; therefore, a deep understanding of its functioning in the nervou...

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Autores principales: Kuczynska, Zuzanna, Metin, Erkan, Liput, Michal, Buzanska, Leonora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750669/
https://www.ncbi.nlm.nih.gov/pubmed/35011673
http://dx.doi.org/10.3390/cells11010111
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author Kuczynska, Zuzanna
Metin, Erkan
Liput, Michal
Buzanska, Leonora
author_facet Kuczynska, Zuzanna
Metin, Erkan
Liput, Michal
Buzanska, Leonora
author_sort Kuczynska, Zuzanna
collection PubMed
description The peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a well-known transcriptional coactivator involved in mitochondrial biogenesis. PGC-1α is implicated in the pathophysiology of many neurodegenerative disorders; therefore, a deep understanding of its functioning in the nervous system may lead to the development of new therapeutic strategies. The central nervous system (CNS)-specific isoforms of PGC-1α have been recently identified, and many functions of PGC-1α are assigned to the particular cell types of the central nervous system. In the mice CNS, deficiency of PGC-1α disturbed viability and functioning of interneurons and dopaminergic neurons, followed by alterations in inhibitory signaling and behavioral dysfunction. Furthermore, in the ALS rodent model, PGC-1α protects upper motoneurons from neurodegeneration. PGC-1α is engaged in the generation of neuromuscular junctions by lower motoneurons, protection of photoreceptors, and reduction in oxidative stress in sensory neurons. Furthermore, in the glial cells, PGC-1α is essential for the maturation and proliferation of astrocytes, myelination by oligodendrocytes, and mitophagy and autophagy of microglia. PGC-1α is also necessary for synaptogenesis in the developing brain and the generation and maintenance of synapses in postnatal life. This review provides an outlook of recent studies on the role of PGC-1α in various cells in the central nervous system.
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spelling pubmed-87506692022-01-12 Covering the Role of PGC-1α in the Nervous System Kuczynska, Zuzanna Metin, Erkan Liput, Michal Buzanska, Leonora Cells Review The peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a well-known transcriptional coactivator involved in mitochondrial biogenesis. PGC-1α is implicated in the pathophysiology of many neurodegenerative disorders; therefore, a deep understanding of its functioning in the nervous system may lead to the development of new therapeutic strategies. The central nervous system (CNS)-specific isoforms of PGC-1α have been recently identified, and many functions of PGC-1α are assigned to the particular cell types of the central nervous system. In the mice CNS, deficiency of PGC-1α disturbed viability and functioning of interneurons and dopaminergic neurons, followed by alterations in inhibitory signaling and behavioral dysfunction. Furthermore, in the ALS rodent model, PGC-1α protects upper motoneurons from neurodegeneration. PGC-1α is engaged in the generation of neuromuscular junctions by lower motoneurons, protection of photoreceptors, and reduction in oxidative stress in sensory neurons. Furthermore, in the glial cells, PGC-1α is essential for the maturation and proliferation of astrocytes, myelination by oligodendrocytes, and mitophagy and autophagy of microglia. PGC-1α is also necessary for synaptogenesis in the developing brain and the generation and maintenance of synapses in postnatal life. This review provides an outlook of recent studies on the role of PGC-1α in various cells in the central nervous system. MDPI 2021-12-30 /pmc/articles/PMC8750669/ /pubmed/35011673 http://dx.doi.org/10.3390/cells11010111 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kuczynska, Zuzanna
Metin, Erkan
Liput, Michal
Buzanska, Leonora
Covering the Role of PGC-1α in the Nervous System
title Covering the Role of PGC-1α in the Nervous System
title_full Covering the Role of PGC-1α in the Nervous System
title_fullStr Covering the Role of PGC-1α in the Nervous System
title_full_unstemmed Covering the Role of PGC-1α in the Nervous System
title_short Covering the Role of PGC-1α in the Nervous System
title_sort covering the role of pgc-1α in the nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750669/
https://www.ncbi.nlm.nih.gov/pubmed/35011673
http://dx.doi.org/10.3390/cells11010111
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