A Novel Kinase Inhibitor AX-0085 Inhibits Interferon-γ-Mediated Induction of PD-L1 Expression and Promotes Immune Reaction to Lung Adenocarcinoma Cells

In this study, we describe a novel kinase inhibitor AX-0085 which can suppress the induction of PD-L1 expression by Interferon-γ (IFN-γ) in lung adenocarcinoma (LUAD) cells. AX-0085 effectively blocks JAK2/STAT1 signaling initiated by IFN-γ treatment and prevents nuclear localization of STAT1. Impor...

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Detalles Bibliográficos
Autores principales: Kim, Jusong, Jang, Haeyeon, Lee, Gyu Jin, Hur, Yelim, Keum, Juhee, Jo, Jung Ki, Yun, Si-Eun, Park, Sung Jun, Park, Young Jun, Choi, Myeong Jun, Kim, Kye-Seong, Kim, Jaesang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750969/
https://www.ncbi.nlm.nih.gov/pubmed/35011581
http://dx.doi.org/10.3390/cells11010019

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