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TUBE Project: Transport-Derived Ultrafines and the Brain Effects

The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitiv...

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Autores principales: Martikainen, Maria-Viola, Aakko-Saksa, Päivi, van den Broek, Lenie, Cassee, Flemming R., Carare, Roxana O., Chew, Sweelin, Dinnyes, Andras, Giugno, Rosalba, Kanninen, Katja M., Malm, Tarja, Muala, Ala, Nedergaard, Maiken, Oudin, Anna, Oyola, Pedro, Pfeiffer, Tobias V., Rönkkö, Topi, Saarikoski, Sanna, Sandström, Thomas, Schins, Roel P. F., Topinka, Jan, Yang, Mo, Zeng, Xiaowen, Westerink, Remco H. S., Jalava, Pasi I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751045/
https://www.ncbi.nlm.nih.gov/pubmed/35010571
http://dx.doi.org/10.3390/ijerph19010311
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author Martikainen, Maria-Viola
Aakko-Saksa, Päivi
van den Broek, Lenie
Cassee, Flemming R.
Carare, Roxana O.
Chew, Sweelin
Dinnyes, Andras
Giugno, Rosalba
Kanninen, Katja M.
Malm, Tarja
Muala, Ala
Nedergaard, Maiken
Oudin, Anna
Oyola, Pedro
Pfeiffer, Tobias V.
Rönkkö, Topi
Saarikoski, Sanna
Sandström, Thomas
Schins, Roel P. F.
Topinka, Jan
Yang, Mo
Zeng, Xiaowen
Westerink, Remco H. S.
Jalava, Pasi I.
author_facet Martikainen, Maria-Viola
Aakko-Saksa, Päivi
van den Broek, Lenie
Cassee, Flemming R.
Carare, Roxana O.
Chew, Sweelin
Dinnyes, Andras
Giugno, Rosalba
Kanninen, Katja M.
Malm, Tarja
Muala, Ala
Nedergaard, Maiken
Oudin, Anna
Oyola, Pedro
Pfeiffer, Tobias V.
Rönkkö, Topi
Saarikoski, Sanna
Sandström, Thomas
Schins, Roel P. F.
Topinka, Jan
Yang, Mo
Zeng, Xiaowen
Westerink, Remco H. S.
Jalava, Pasi I.
author_sort Martikainen, Maria-Viola
collection PubMed
description The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, and Alzheimer’s disease. However, the exact air pollutant compositions and exposure scenarios leading to these adverse health effects are not known. Although several components of air pollution may be at play, recent experimental studies point to a key role of ultrafine particles (UFPs). While the importance of UFPs has been recognized, almost nothing is known about the smallest fraction of UFPs, and only >23 nm emissions are regulated in the EU. Moreover, the role of the semivolatile fraction of the emissions has been neglected. The Transport-Derived Ultrafines and the Brain Effects (TUBE) project will increase knowledge on harmful ultrafine air pollutants, as well as semivolatile compounds related to adverse health effects. By including all the major current combustion and emission control technologies, the TUBE project aims to provide new information on the adverse health effects of current traffic, as well as information for decision makers to develop more effective emission legislation. Most importantly, the TUBE project will include adverse health effects beyond the respiratory system; TUBE will assess how air pollution affects the brain and how air pollution particles might be removed from the brain. The purpose of this report is to describe the TUBE project, its background, and its goals.
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spelling pubmed-87510452022-01-12 TUBE Project: Transport-Derived Ultrafines and the Brain Effects Martikainen, Maria-Viola Aakko-Saksa, Päivi van den Broek, Lenie Cassee, Flemming R. Carare, Roxana O. Chew, Sweelin Dinnyes, Andras Giugno, Rosalba Kanninen, Katja M. Malm, Tarja Muala, Ala Nedergaard, Maiken Oudin, Anna Oyola, Pedro Pfeiffer, Tobias V. Rönkkö, Topi Saarikoski, Sanna Sandström, Thomas Schins, Roel P. F. Topinka, Jan Yang, Mo Zeng, Xiaowen Westerink, Remco H. S. Jalava, Pasi I. Int J Environ Res Public Health Project Report The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, and Alzheimer’s disease. However, the exact air pollutant compositions and exposure scenarios leading to these adverse health effects are not known. Although several components of air pollution may be at play, recent experimental studies point to a key role of ultrafine particles (UFPs). While the importance of UFPs has been recognized, almost nothing is known about the smallest fraction of UFPs, and only >23 nm emissions are regulated in the EU. Moreover, the role of the semivolatile fraction of the emissions has been neglected. The Transport-Derived Ultrafines and the Brain Effects (TUBE) project will increase knowledge on harmful ultrafine air pollutants, as well as semivolatile compounds related to adverse health effects. By including all the major current combustion and emission control technologies, the TUBE project aims to provide new information on the adverse health effects of current traffic, as well as information for decision makers to develop more effective emission legislation. Most importantly, the TUBE project will include adverse health effects beyond the respiratory system; TUBE will assess how air pollution affects the brain and how air pollution particles might be removed from the brain. The purpose of this report is to describe the TUBE project, its background, and its goals. MDPI 2021-12-28 /pmc/articles/PMC8751045/ /pubmed/35010571 http://dx.doi.org/10.3390/ijerph19010311 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Project Report
Martikainen, Maria-Viola
Aakko-Saksa, Päivi
van den Broek, Lenie
Cassee, Flemming R.
Carare, Roxana O.
Chew, Sweelin
Dinnyes, Andras
Giugno, Rosalba
Kanninen, Katja M.
Malm, Tarja
Muala, Ala
Nedergaard, Maiken
Oudin, Anna
Oyola, Pedro
Pfeiffer, Tobias V.
Rönkkö, Topi
Saarikoski, Sanna
Sandström, Thomas
Schins, Roel P. F.
Topinka, Jan
Yang, Mo
Zeng, Xiaowen
Westerink, Remco H. S.
Jalava, Pasi I.
TUBE Project: Transport-Derived Ultrafines and the Brain Effects
title TUBE Project: Transport-Derived Ultrafines and the Brain Effects
title_full TUBE Project: Transport-Derived Ultrafines and the Brain Effects
title_fullStr TUBE Project: Transport-Derived Ultrafines and the Brain Effects
title_full_unstemmed TUBE Project: Transport-Derived Ultrafines and the Brain Effects
title_short TUBE Project: Transport-Derived Ultrafines and the Brain Effects
title_sort tube project: transport-derived ultrafines and the brain effects
topic Project Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751045/
https://www.ncbi.nlm.nih.gov/pubmed/35010571
http://dx.doi.org/10.3390/ijerph19010311
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