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Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis
Osteoarthritis, as a degenerative disease, is a common problem and results in high socioeconomic costs and rates of disability. The most commonly affected joint is the knee and characterized by progressive destruction of articular cartilage, loss of extracellular matrix, and progressive inflammation...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751117/ https://www.ncbi.nlm.nih.gov/pubmed/35012666 http://dx.doi.org/10.1186/s13287-021-02689-9 |
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author | Xiang, Xiao-Na Zhu, Si-Yi He, Hong-Chen Yu, Xi Xu, Yang He, Cheng-Qi |
author_facet | Xiang, Xiao-Na Zhu, Si-Yi He, Hong-Chen Yu, Xi Xu, Yang He, Cheng-Qi |
author_sort | Xiang, Xiao-Na |
collection | PubMed |
description | Osteoarthritis, as a degenerative disease, is a common problem and results in high socioeconomic costs and rates of disability. The most commonly affected joint is the knee and characterized by progressive destruction of articular cartilage, loss of extracellular matrix, and progressive inflammation. Mesenchymal stromal cell (MSC)-based therapy has been explored as a new regenerative treatment for knee osteoarthritis in recent years. However, the detailed functions of MSC-based therapy and related mechanism, especially of cartilage regeneration, have not been explained. Hence, this review summarized how to choose, authenticate, and culture different origins of MSCs and derived exosomes. Moreover, clinical application and the latest mechanistical findings of MSC-based therapy in cartilage regeneration were also demonstrated. |
format | Online Article Text |
id | pubmed-8751117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-87511172022-01-11 Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis Xiang, Xiao-Na Zhu, Si-Yi He, Hong-Chen Yu, Xi Xu, Yang He, Cheng-Qi Stem Cell Res Ther Review Osteoarthritis, as a degenerative disease, is a common problem and results in high socioeconomic costs and rates of disability. The most commonly affected joint is the knee and characterized by progressive destruction of articular cartilage, loss of extracellular matrix, and progressive inflammation. Mesenchymal stromal cell (MSC)-based therapy has been explored as a new regenerative treatment for knee osteoarthritis in recent years. However, the detailed functions of MSC-based therapy and related mechanism, especially of cartilage regeneration, have not been explained. Hence, this review summarized how to choose, authenticate, and culture different origins of MSCs and derived exosomes. Moreover, clinical application and the latest mechanistical findings of MSC-based therapy in cartilage regeneration were also demonstrated. BioMed Central 2022-01-10 /pmc/articles/PMC8751117/ /pubmed/35012666 http://dx.doi.org/10.1186/s13287-021-02689-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Xiang, Xiao-Na Zhu, Si-Yi He, Hong-Chen Yu, Xi Xu, Yang He, Cheng-Qi Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis |
title | Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis |
title_full | Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis |
title_fullStr | Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis |
title_full_unstemmed | Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis |
title_short | Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis |
title_sort | mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751117/ https://www.ncbi.nlm.nih.gov/pubmed/35012666 http://dx.doi.org/10.1186/s13287-021-02689-9 |
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