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Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

BACKGROUND: Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson’s disease (PD). Aggregated α-synuclein pathologically defines PD. Recent studies identified elevated LRRK2 expression in pro-inflammatory CD16+ monocytes in idiopathic PD, as well as increased ph...

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Detalles Bibliográficos
Autores principales:	Xu, Enquan, Boddu, Ravindra, Abdelmotilib, Hisham A., Sokratian, Arpine, Kelly, Kaela, Liu, Zhiyong, Bryant, Nicole, Chandra, Sidhanth, Carlisle, Samantha M., Lefkowitz, Elliot J., Harms, Ashley S., Benveniste, Etty N., Yacoubian, Talene A., Volpicelli-Daley, Laura A., Standaert, David G., West, Andrew B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751347/ https://www.ncbi.nlm.nih.gov/pubmed/35012605 http://dx.doi.org/10.1186/s13024-021-00509-5

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