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ANTI-FUNGAL ACTIVITY OF ACALYPHA WILKESIANA: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE

BACKGROUND: Acalypha wilkesiana (AW, a popular medicinal plant has been used in traditional medicine to treat a variety of skin disorders including pityriasis versicolor and seborrheic dermatitis. As a prelude to clinical trials in humans, an experimental study was carried out to determine the spect...

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Autores principales: Sherifat, Katibi Oludolapo, Itohan, Aboh Mercy, Adeola, Salawu Oluwakayinsola, Adeola, Kola-Mustapha, Aderemi, Olatunji Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: African Traditional Herbal Medicine Supporters Initiative (ATHMSI) 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751394/
https://www.ncbi.nlm.nih.gov/pubmed/35047727
http://dx.doi.org/10.21010/Ajid.v16i1.4
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author Sherifat, Katibi Oludolapo
Itohan, Aboh Mercy
Adeola, Salawu Oluwakayinsola
Adeola, Kola-Mustapha
Aderemi, Olatunji Lawrence
author_facet Sherifat, Katibi Oludolapo
Itohan, Aboh Mercy
Adeola, Salawu Oluwakayinsola
Adeola, Kola-Mustapha
Aderemi, Olatunji Lawrence
author_sort Sherifat, Katibi Oludolapo
collection PubMed
description BACKGROUND: Acalypha wilkesiana (AW, a popular medicinal plant has been used in traditional medicine to treat a variety of skin disorders including pityriasis versicolor and seborrheic dermatitis. As a prelude to clinical trials in humans, an experimental study was carried out to determine the spectrum of antifungal activity of 2 variants of the Acalypha wilkesiana plant. MATERIALS AND METHODS: The ethanol extract and herbal cream formulation of the dried leaves of 2 cultivars (Macrophylla & Hoffmani) of Acalypha wilkesiana were investigated for in-vitro antifungal activity by disc diffusion and micro-broth dilution techniques. Organisms tested were typed cultures of Malassezia furfur, Candida albicans and Trichophyton rubrum; and clinical strains of Microsporum canis and Epidermophyton floccosum. RESULTS: Both cultivars (Macrophylla and Hoffmanii) of the plant showed good activity against all the fungi tested except Microsporum canis (8.0±0.00; 7.00±0.00 mm). The greatest activity was observed against Trichophyton rubrum (22.0±0.00; 24.00±0.00 mm). The Minimum Inhibitory Concentration (MIC) of the crude extract ranged between 0.25 and 8 mg/ml for all organisms, while that of the herbal cream was 0.31-8mg/ml. The lowest MIC was seen with Candida albicans for both varieties of the plant. The Acalypha wilkesiana Hoffmanii demonstrated a greater activity against Candida albicans and Malassezia furufur than the A. wilkesiana Macrophylla. CONCLUSION: This study reveals Acalypha wilkesiana leaf extract has potential for development as a cream that can be used to treat superficial fungal skin infections.
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spelling pubmed-87513942022-01-18 ANTI-FUNGAL ACTIVITY OF ACALYPHA WILKESIANA: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE Sherifat, Katibi Oludolapo Itohan, Aboh Mercy Adeola, Salawu Oluwakayinsola Adeola, Kola-Mustapha Aderemi, Olatunji Lawrence Afr J Infect Dis Article BACKGROUND: Acalypha wilkesiana (AW, a popular medicinal plant has been used in traditional medicine to treat a variety of skin disorders including pityriasis versicolor and seborrheic dermatitis. As a prelude to clinical trials in humans, an experimental study was carried out to determine the spectrum of antifungal activity of 2 variants of the Acalypha wilkesiana plant. MATERIALS AND METHODS: The ethanol extract and herbal cream formulation of the dried leaves of 2 cultivars (Macrophylla & Hoffmani) of Acalypha wilkesiana were investigated for in-vitro antifungal activity by disc diffusion and micro-broth dilution techniques. Organisms tested were typed cultures of Malassezia furfur, Candida albicans and Trichophyton rubrum; and clinical strains of Microsporum canis and Epidermophyton floccosum. RESULTS: Both cultivars (Macrophylla and Hoffmanii) of the plant showed good activity against all the fungi tested except Microsporum canis (8.0±0.00; 7.00±0.00 mm). The greatest activity was observed against Trichophyton rubrum (22.0±0.00; 24.00±0.00 mm). The Minimum Inhibitory Concentration (MIC) of the crude extract ranged between 0.25 and 8 mg/ml for all organisms, while that of the herbal cream was 0.31-8mg/ml. The lowest MIC was seen with Candida albicans for both varieties of the plant. The Acalypha wilkesiana Hoffmanii demonstrated a greater activity against Candida albicans and Malassezia furufur than the A. wilkesiana Macrophylla. CONCLUSION: This study reveals Acalypha wilkesiana leaf extract has potential for development as a cream that can be used to treat superficial fungal skin infections. African Traditional Herbal Medicine Supporters Initiative (ATHMSI) 2021-12-21 /pmc/articles/PMC8751394/ /pubmed/35047727 http://dx.doi.org/10.21010/Ajid.v16i1.4 Text en Copyright: © 2022 Afr. J. Infect. Diseases https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
spellingShingle Article
Sherifat, Katibi Oludolapo
Itohan, Aboh Mercy
Adeola, Salawu Oluwakayinsola
Adeola, Kola-Mustapha
Aderemi, Olatunji Lawrence
ANTI-FUNGAL ACTIVITY OF ACALYPHA WILKESIANA: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE
title ANTI-FUNGAL ACTIVITY OF ACALYPHA WILKESIANA: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE
title_full ANTI-FUNGAL ACTIVITY OF ACALYPHA WILKESIANA: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE
title_fullStr ANTI-FUNGAL ACTIVITY OF ACALYPHA WILKESIANA: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE
title_full_unstemmed ANTI-FUNGAL ACTIVITY OF ACALYPHA WILKESIANA: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE
title_short ANTI-FUNGAL ACTIVITY OF ACALYPHA WILKESIANA: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE
title_sort anti-fungal activity of acalypha wilkesiana: a preliminary study of fungal isolates of clinical significance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751394/
https://www.ncbi.nlm.nih.gov/pubmed/35047727
http://dx.doi.org/10.21010/Ajid.v16i1.4
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