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Delayed Presentation in Chiari Malformation

INTRODUCTION: Chiari malformations are a group of clinicopathological entities with a variety of clinical presentations, different pathophysiology, and variable outcomes. It has a typical set of clinical presentation. In this study is to observe the different clinical presentations of the patients w...

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Autores principales: Rafay, Muhammad, Gulzar, Farhan, Jafri, Hassan Masood, Sharif, Salman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751530/
https://www.ncbi.nlm.nih.gov/pubmed/35071065
http://dx.doi.org/10.4103/ajns.AJNS_120_21
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author Rafay, Muhammad
Gulzar, Farhan
Jafri, Hassan Masood
Sharif, Salman
author_facet Rafay, Muhammad
Gulzar, Farhan
Jafri, Hassan Masood
Sharif, Salman
author_sort Rafay, Muhammad
collection PubMed
description INTRODUCTION: Chiari malformations are a group of clinicopathological entities with a variety of clinical presentations, different pathophysiology, and variable outcomes. It has a typical set of clinical presentation. In this study is to observe the different clinical presentations of the patients with Chiari malformation in our population. As the time of initial presentation is delayed that might change the sign and symptoms with which patient initially presents. MATERIALS AND METHODS: This was a cross-sectional observational study with prospectively collected data of 46 patients with Chiari malformation. The duration of the study is from 2017 to 2020. Patient's data will be compiled and analyzed through Statistical Package for Social Sciences (SPSS) Version 25. Qualitative variables are presented as frequencies and percentages. Quantitative variables are presented as mean ± standard deviation. Effect modifiers are controlled through stratification. The Chi-square test is used for finding association between categorical variables. P ≤ 0.05 is considered as statistically significant. RESULTS: According to our data 36% of our patients presented with motor weakness which is followed by sensory deficit, however in previous literature headache was the commonest clinical presentation. CONCLUSION: Clinical presentation in our population differs from other studies and the reason behind this is the delayed presentation of the patient and lack of awareness of disease and ultimately it will alter the outcome of disease and treatment.
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spelling pubmed-87515302022-01-21 Delayed Presentation in Chiari Malformation Rafay, Muhammad Gulzar, Farhan Jafri, Hassan Masood Sharif, Salman Asian J Neurosurg Original Article INTRODUCTION: Chiari malformations are a group of clinicopathological entities with a variety of clinical presentations, different pathophysiology, and variable outcomes. It has a typical set of clinical presentation. In this study is to observe the different clinical presentations of the patients with Chiari malformation in our population. As the time of initial presentation is delayed that might change the sign and symptoms with which patient initially presents. MATERIALS AND METHODS: This was a cross-sectional observational study with prospectively collected data of 46 patients with Chiari malformation. The duration of the study is from 2017 to 2020. Patient's data will be compiled and analyzed through Statistical Package for Social Sciences (SPSS) Version 25. Qualitative variables are presented as frequencies and percentages. Quantitative variables are presented as mean ± standard deviation. Effect modifiers are controlled through stratification. The Chi-square test is used for finding association between categorical variables. P ≤ 0.05 is considered as statistically significant. RESULTS: According to our data 36% of our patients presented with motor weakness which is followed by sensory deficit, however in previous literature headache was the commonest clinical presentation. CONCLUSION: Clinical presentation in our population differs from other studies and the reason behind this is the delayed presentation of the patient and lack of awareness of disease and ultimately it will alter the outcome of disease and treatment. Wolters Kluwer - Medknow 2021-12-18 /pmc/articles/PMC8751530/ /pubmed/35071065 http://dx.doi.org/10.4103/ajns.AJNS_120_21 Text en Copyright: © 2021 Asian Journal of Neurosurgery https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Rafay, Muhammad
Gulzar, Farhan
Jafri, Hassan Masood
Sharif, Salman
Delayed Presentation in Chiari Malformation
title Delayed Presentation in Chiari Malformation
title_full Delayed Presentation in Chiari Malformation
title_fullStr Delayed Presentation in Chiari Malformation
title_full_unstemmed Delayed Presentation in Chiari Malformation
title_short Delayed Presentation in Chiari Malformation
title_sort delayed presentation in chiari malformation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751530/
https://www.ncbi.nlm.nih.gov/pubmed/35071065
http://dx.doi.org/10.4103/ajns.AJNS_120_21
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