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A Comparative Study of Microneedling Combined with Topical 5-Fluorouracil versus Microneedling Alone in Treatment of Localized Stable Vitiligo
CONTEXT: Vitiligo is an acquired pigmentary disorder of the skin that is characterized by circumscribed, depigmented macules, and patches. AIMS: To compare the therapeutic efficacy and safety of microneedling combined with topical 5-fluorouracil solution versus microneedling alone on stable patches...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751692/ https://www.ncbi.nlm.nih.gov/pubmed/35068531 http://dx.doi.org/10.4103/ijd.ijd_130_21 |
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author | Chhabra, Shaiphali Chahar, Yatendra S Singh, Akanksha |
author_facet | Chhabra, Shaiphali Chahar, Yatendra S Singh, Akanksha |
author_sort | Chhabra, Shaiphali |
collection | PubMed |
description | CONTEXT: Vitiligo is an acquired pigmentary disorder of the skin that is characterized by circumscribed, depigmented macules, and patches. AIMS: To compare the therapeutic efficacy and safety of microneedling combined with topical 5-fluorouracil solution versus microneedling alone on stable patches of vitiligo. SETTINGS AND DESIGN: Hospital-based interventional prospective study. METHODS AND MATERIAL: We selected 46 patients in the age group of 10–50 years having patch stability of at least 1-year duration. The patients were randomly assigned into two groups of 23 patients each. Group A was treated with microneedling followed by application of 5-fluorouracil which was available in the form of a solution (50 mg/mL) whereas Group B was treated with microneedling alone. The procedure was repeated after every 15 days up to 4 months and patient follow-up along with the grading of repigmentation was done till 6 months. The side effects were noted. STATISTICAL ANALYSIS USED: Statistical Package for Social Sciences (SPSS) software, version 25.0. The results were analyzed using the Chi-square test and t-test and P < 0.05 was considered significant. RESULTS: At the end of 6 months, excellent response (>75% repigmentation) was reported in 35 patches (48.6%) in Group A treated with microneedling combined with 5-fluorouracil whereas only 12 patches (16.9%) showed an excellent response in Group B treated with microneedling alone. CONCLUSIONS: Combining microneedling with 5-fluorouracil is a simple, safe, well tolerable, and effective modality than microneedling alone for treating small localized vitiligo patches. |
format | Online Article Text |
id | pubmed-8751692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-87516922022-01-21 A Comparative Study of Microneedling Combined with Topical 5-Fluorouracil versus Microneedling Alone in Treatment of Localized Stable Vitiligo Chhabra, Shaiphali Chahar, Yatendra S Singh, Akanksha Indian J Dermatol Original Article CONTEXT: Vitiligo is an acquired pigmentary disorder of the skin that is characterized by circumscribed, depigmented macules, and patches. AIMS: To compare the therapeutic efficacy and safety of microneedling combined with topical 5-fluorouracil solution versus microneedling alone on stable patches of vitiligo. SETTINGS AND DESIGN: Hospital-based interventional prospective study. METHODS AND MATERIAL: We selected 46 patients in the age group of 10–50 years having patch stability of at least 1-year duration. The patients were randomly assigned into two groups of 23 patients each. Group A was treated with microneedling followed by application of 5-fluorouracil which was available in the form of a solution (50 mg/mL) whereas Group B was treated with microneedling alone. The procedure was repeated after every 15 days up to 4 months and patient follow-up along with the grading of repigmentation was done till 6 months. The side effects were noted. STATISTICAL ANALYSIS USED: Statistical Package for Social Sciences (SPSS) software, version 25.0. The results were analyzed using the Chi-square test and t-test and P < 0.05 was considered significant. RESULTS: At the end of 6 months, excellent response (>75% repigmentation) was reported in 35 patches (48.6%) in Group A treated with microneedling combined with 5-fluorouracil whereas only 12 patches (16.9%) showed an excellent response in Group B treated with microneedling alone. CONCLUSIONS: Combining microneedling with 5-fluorouracil is a simple, safe, well tolerable, and effective modality than microneedling alone for treating small localized vitiligo patches. Wolters Kluwer - Medknow 2021 /pmc/articles/PMC8751692/ /pubmed/35068531 http://dx.doi.org/10.4103/ijd.ijd_130_21 Text en Copyright: © 2021 Indian Journal of Dermatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Chhabra, Shaiphali Chahar, Yatendra S Singh, Akanksha A Comparative Study of Microneedling Combined with Topical 5-Fluorouracil versus Microneedling Alone in Treatment of Localized Stable Vitiligo |
title | A Comparative Study of Microneedling Combined with Topical 5-Fluorouracil versus Microneedling Alone in Treatment of Localized Stable Vitiligo |
title_full | A Comparative Study of Microneedling Combined with Topical 5-Fluorouracil versus Microneedling Alone in Treatment of Localized Stable Vitiligo |
title_fullStr | A Comparative Study of Microneedling Combined with Topical 5-Fluorouracil versus Microneedling Alone in Treatment of Localized Stable Vitiligo |
title_full_unstemmed | A Comparative Study of Microneedling Combined with Topical 5-Fluorouracil versus Microneedling Alone in Treatment of Localized Stable Vitiligo |
title_short | A Comparative Study of Microneedling Combined with Topical 5-Fluorouracil versus Microneedling Alone in Treatment of Localized Stable Vitiligo |
title_sort | comparative study of microneedling combined with topical 5-fluorouracil versus microneedling alone in treatment of localized stable vitiligo |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751692/ https://www.ncbi.nlm.nih.gov/pubmed/35068531 http://dx.doi.org/10.4103/ijd.ijd_130_21 |
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