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Dynamic Thiol/Disulphide Homeostasis in Acute Urticaria

BACKGROUND: Urticaria is an unknown, sudden, and itchy skin disease that is recognized with redness, swelling, and is sometimes seen with angioedema. It is classified as acute or chronic, depending on the duration of symptoms. Thiols in plasma are powerful antioxidants that physiologically eliminate...

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Autores principales: Otal, Yavuz, Koz, Neslihan Özkök, Kahraman, Fatih Ahmet, Güllü Haydar Ercan, F., Erel, Özcan, Avcıoğlu, Gamze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751716/
https://www.ncbi.nlm.nih.gov/pubmed/35068496
http://dx.doi.org/10.4103/ijd.IJD_152_19
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author Otal, Yavuz
Koz, Neslihan Özkök
Kahraman, Fatih Ahmet
Güllü Haydar Ercan, F.
Erel, Özcan
Avcıoğlu, Gamze
author_facet Otal, Yavuz
Koz, Neslihan Özkök
Kahraman, Fatih Ahmet
Güllü Haydar Ercan, F.
Erel, Özcan
Avcıoğlu, Gamze
author_sort Otal, Yavuz
collection PubMed
description BACKGROUND: Urticaria is an unknown, sudden, and itchy skin disease that is recognized with redness, swelling, and is sometimes seen with angioedema. It is classified as acute or chronic, depending on the duration of symptoms. Thiols in plasma are powerful antioxidants that physiologically eliminate free radicals. The mostly and rapidly affected proteins are thiols that contain the sulfhydryl group. In the present study, the thiol/disulfide homeostasis was investigated as a brand new indicator of oxidative stress in patients who had acute urticaria and presented to the emergency department. OBJECTIVE: In the present study, the thiol/disulfide homeostasis, ischemia-modified albumin (IMA), and and neutrophil lymphocyte ratio (N/L ratio) were investigated in the etiopathogenesis of acute urticaria. MATERIAL AND METHOD: A total of 37 patients and 40 healthy volunteers were included in the study. Thiol/disulfide homeostasis (TDH) [total thiol-native thiol/disulfide changes] was measured in both groups (patient group and control group) using a brand novel method developed by Erel and Neselioglu. Half of the difference between total thiol and native thiol concentrations gives the amount of disulfide bond. RESULTS: Total thiol and native thiol levels in blood were found to be low. The levels of total thiol (P = 0.218) and native thiol (P = 0,001) were significantly lower in patients with acute urticaria than in the control group. At the same time, the level of disulfide was significantly higher in the patient group than in the control group (P = <0.001). The level of IMA was higher in the patient group than in the control group (P < 0.001). CONCLUSION: While total thiol and native thiol are low in acute urticaria, the levels of disulfide and IMA are high.
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spelling pubmed-87517162022-01-21 Dynamic Thiol/Disulphide Homeostasis in Acute Urticaria Otal, Yavuz Koz, Neslihan Özkök Kahraman, Fatih Ahmet Güllü Haydar Ercan, F. Erel, Özcan Avcıoğlu, Gamze Indian J Dermatol Original Article BACKGROUND: Urticaria is an unknown, sudden, and itchy skin disease that is recognized with redness, swelling, and is sometimes seen with angioedema. It is classified as acute or chronic, depending on the duration of symptoms. Thiols in plasma are powerful antioxidants that physiologically eliminate free radicals. The mostly and rapidly affected proteins are thiols that contain the sulfhydryl group. In the present study, the thiol/disulfide homeostasis was investigated as a brand new indicator of oxidative stress in patients who had acute urticaria and presented to the emergency department. OBJECTIVE: In the present study, the thiol/disulfide homeostasis, ischemia-modified albumin (IMA), and and neutrophil lymphocyte ratio (N/L ratio) were investigated in the etiopathogenesis of acute urticaria. MATERIAL AND METHOD: A total of 37 patients and 40 healthy volunteers were included in the study. Thiol/disulfide homeostasis (TDH) [total thiol-native thiol/disulfide changes] was measured in both groups (patient group and control group) using a brand novel method developed by Erel and Neselioglu. Half of the difference between total thiol and native thiol concentrations gives the amount of disulfide bond. RESULTS: Total thiol and native thiol levels in blood were found to be low. The levels of total thiol (P = 0.218) and native thiol (P = 0,001) were significantly lower in patients with acute urticaria than in the control group. At the same time, the level of disulfide was significantly higher in the patient group than in the control group (P = <0.001). The level of IMA was higher in the patient group than in the control group (P < 0.001). CONCLUSION: While total thiol and native thiol are low in acute urticaria, the levels of disulfide and IMA are high. Wolters Kluwer - Medknow 2021 /pmc/articles/PMC8751716/ /pubmed/35068496 http://dx.doi.org/10.4103/ijd.IJD_152_19 Text en Copyright: © 2021 Indian Journal of Dermatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Otal, Yavuz
Koz, Neslihan Özkök
Kahraman, Fatih Ahmet
Güllü Haydar Ercan, F.
Erel, Özcan
Avcıoğlu, Gamze
Dynamic Thiol/Disulphide Homeostasis in Acute Urticaria
title Dynamic Thiol/Disulphide Homeostasis in Acute Urticaria
title_full Dynamic Thiol/Disulphide Homeostasis in Acute Urticaria
title_fullStr Dynamic Thiol/Disulphide Homeostasis in Acute Urticaria
title_full_unstemmed Dynamic Thiol/Disulphide Homeostasis in Acute Urticaria
title_short Dynamic Thiol/Disulphide Homeostasis in Acute Urticaria
title_sort dynamic thiol/disulphide homeostasis in acute urticaria
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751716/
https://www.ncbi.nlm.nih.gov/pubmed/35068496
http://dx.doi.org/10.4103/ijd.IJD_152_19
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