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Elevated Serum Endocan Levels in Patients with Rosacea: A New Therapeutic Target?
BACKGROUND: Rosacea is a chronic inflammatory skin disease whose etiopathogenesis is still unknown. Previous studies have shown a relationship between certain inflammatory disorders and serum endocan levels. Endocan (previously known as endothelial cell-specific molecule 1) might play a role in the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751717/ https://www.ncbi.nlm.nih.gov/pubmed/35068507 http://dx.doi.org/10.4103/ijd.ijd_401_21 |
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author | Kılıc, Sevilay Mermutlu, Selda I Şehitoğlu, Hilal Ekinci, Alper |
author_facet | Kılıc, Sevilay Mermutlu, Selda I Şehitoğlu, Hilal Ekinci, Alper |
author_sort | Kılıc, Sevilay |
collection | PubMed |
description | BACKGROUND: Rosacea is a chronic inflammatory skin disease whose etiopathogenesis is still unknown. Previous studies have shown a relationship between certain inflammatory disorders and serum endocan levels. Endocan (previously known as endothelial cell-specific molecule 1) might play a role in the pathogenesis of various inflammatory diseases. AIMS AND OBJECTIVES: Our study aimed to evaluate serum endocan levels in patients with rosacea to investigate the association of endocan with the demographic data. MATERIALS AND METHODS: The study recruited individuals aged ≥18 years who voluntarily agreed to participate in the study. The participants included 37 women (mean age: 48.29 ± 12.08 years) and 13 men (mean age: 52.23 ± 13.34 years) diagnosed with rosacea, and 37 women (mean age: 49.18 ± 16.6 years) and 13 men (mean age: 53.69 ± 11.30 years) selected as controls. Both groups were matched according to age and sex. The rosacea diagnosis was based on clinical examination findings, and serum endocan levels were measured using the method of enzyme-linked immunosorbent assay (ELISA). The statistical significance of the data was determined by the Mann–Whitney U test, and a value of P < 0.05 was considered statistically significant. RESULTS: Serum endocan levels differed significantly between the patients with rosacea and the control group (P < 0.05). CONCLUSION: Circulating endocan might be a new marker related to disease progression in patients with rosacea. Further investigation is needed to determine whether endocan levels could become a new therapeutic target in rosacea, a disease that still cannot be fully cured. |
format | Online Article Text |
id | pubmed-8751717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-87517172022-01-21 Elevated Serum Endocan Levels in Patients with Rosacea: A New Therapeutic Target? Kılıc, Sevilay Mermutlu, Selda I Şehitoğlu, Hilal Ekinci, Alper Indian J Dermatol Short Communication BACKGROUND: Rosacea is a chronic inflammatory skin disease whose etiopathogenesis is still unknown. Previous studies have shown a relationship between certain inflammatory disorders and serum endocan levels. Endocan (previously known as endothelial cell-specific molecule 1) might play a role in the pathogenesis of various inflammatory diseases. AIMS AND OBJECTIVES: Our study aimed to evaluate serum endocan levels in patients with rosacea to investigate the association of endocan with the demographic data. MATERIALS AND METHODS: The study recruited individuals aged ≥18 years who voluntarily agreed to participate in the study. The participants included 37 women (mean age: 48.29 ± 12.08 years) and 13 men (mean age: 52.23 ± 13.34 years) diagnosed with rosacea, and 37 women (mean age: 49.18 ± 16.6 years) and 13 men (mean age: 53.69 ± 11.30 years) selected as controls. Both groups were matched according to age and sex. The rosacea diagnosis was based on clinical examination findings, and serum endocan levels were measured using the method of enzyme-linked immunosorbent assay (ELISA). The statistical significance of the data was determined by the Mann–Whitney U test, and a value of P < 0.05 was considered statistically significant. RESULTS: Serum endocan levels differed significantly between the patients with rosacea and the control group (P < 0.05). CONCLUSION: Circulating endocan might be a new marker related to disease progression in patients with rosacea. Further investigation is needed to determine whether endocan levels could become a new therapeutic target in rosacea, a disease that still cannot be fully cured. Wolters Kluwer - Medknow 2021 /pmc/articles/PMC8751717/ /pubmed/35068507 http://dx.doi.org/10.4103/ijd.ijd_401_21 Text en Copyright: © 2021 Indian Journal of Dermatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Short Communication Kılıc, Sevilay Mermutlu, Selda I Şehitoğlu, Hilal Ekinci, Alper Elevated Serum Endocan Levels in Patients with Rosacea: A New Therapeutic Target? |
title | Elevated Serum Endocan Levels in Patients with Rosacea: A New Therapeutic Target? |
title_full | Elevated Serum Endocan Levels in Patients with Rosacea: A New Therapeutic Target? |
title_fullStr | Elevated Serum Endocan Levels in Patients with Rosacea: A New Therapeutic Target? |
title_full_unstemmed | Elevated Serum Endocan Levels in Patients with Rosacea: A New Therapeutic Target? |
title_short | Elevated Serum Endocan Levels in Patients with Rosacea: A New Therapeutic Target? |
title_sort | elevated serum endocan levels in patients with rosacea: a new therapeutic target? |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751717/ https://www.ncbi.nlm.nih.gov/pubmed/35068507 http://dx.doi.org/10.4103/ijd.ijd_401_21 |
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