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Does involucrin have a Role in Verruca Vulgaris? A Clinical and Immunohistochemical Study

INTRODUCTION: Several modalities are used in the treatment of verrucae vulgaris; however, their side effects are common. Vitamin D3 has been recently used as a treatment in verruca vulgaris. AIM OF THE WORK: We aimed to assess the expression of involucrin in verrucae before and after intralesional i...

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Autores principales: Akl, Essam M, Sorour, Neveen E, Abdou, Asmaa G, Elesawy, Fatma M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751724/
https://www.ncbi.nlm.nih.gov/pubmed/35068499
http://dx.doi.org/10.4103/ijd.ijd_808_20
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author Akl, Essam M
Sorour, Neveen E
Abdou, Asmaa G
Elesawy, Fatma M
author_facet Akl, Essam M
Sorour, Neveen E
Abdou, Asmaa G
Elesawy, Fatma M
author_sort Akl, Essam M
collection PubMed
description INTRODUCTION: Several modalities are used in the treatment of verrucae vulgaris; however, their side effects are common. Vitamin D3 has been recently used as a treatment in verruca vulgaris. AIM OF THE WORK: We aimed to assess the expression of involucrin in verrucae before and after intralesional injection of vitamin D3 and its correlation with clinical response. SUBJECTS AND METHODS: This study included 60 patients with verrucae vulgaris. These patients were subjected to intralesional injection of vitamin D3 at 3-week intervals for a maximum of five sessions. The pathological assessment was done by skin biopsies obtained from thirty patients before the first session and after the last session of injection and compared to skin biopsies from 30 healthy individuals. RESULTS: The injected verrucae showed complete response in 39 patients (65%), partial response in 15 patients (25%), and no response in 6 patients (10%). Nonsmoker patients had a better response than smokers. Vitamin D3 injections also resulted in increasing involucrin expression and changing its pattern of expression. CONCLUSIONS: Intralesional vitamin D3 is an effective treatment for verrucae vulgaris. Involucrin expression is modified in verrucae.
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spelling pubmed-87517242022-01-21 Does involucrin have a Role in Verruca Vulgaris? A Clinical and Immunohistochemical Study Akl, Essam M Sorour, Neveen E Abdou, Asmaa G Elesawy, Fatma M Indian J Dermatol Original Article INTRODUCTION: Several modalities are used in the treatment of verrucae vulgaris; however, their side effects are common. Vitamin D3 has been recently used as a treatment in verruca vulgaris. AIM OF THE WORK: We aimed to assess the expression of involucrin in verrucae before and after intralesional injection of vitamin D3 and its correlation with clinical response. SUBJECTS AND METHODS: This study included 60 patients with verrucae vulgaris. These patients were subjected to intralesional injection of vitamin D3 at 3-week intervals for a maximum of five sessions. The pathological assessment was done by skin biopsies obtained from thirty patients before the first session and after the last session of injection and compared to skin biopsies from 30 healthy individuals. RESULTS: The injected verrucae showed complete response in 39 patients (65%), partial response in 15 patients (25%), and no response in 6 patients (10%). Nonsmoker patients had a better response than smokers. Vitamin D3 injections also resulted in increasing involucrin expression and changing its pattern of expression. CONCLUSIONS: Intralesional vitamin D3 is an effective treatment for verrucae vulgaris. Involucrin expression is modified in verrucae. Wolters Kluwer - Medknow 2021 /pmc/articles/PMC8751724/ /pubmed/35068499 http://dx.doi.org/10.4103/ijd.ijd_808_20 Text en Copyright: © 2021 Indian Journal of Dermatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Akl, Essam M
Sorour, Neveen E
Abdou, Asmaa G
Elesawy, Fatma M
Does involucrin have a Role in Verruca Vulgaris? A Clinical and Immunohistochemical Study
title Does involucrin have a Role in Verruca Vulgaris? A Clinical and Immunohistochemical Study
title_full Does involucrin have a Role in Verruca Vulgaris? A Clinical and Immunohistochemical Study
title_fullStr Does involucrin have a Role in Verruca Vulgaris? A Clinical and Immunohistochemical Study
title_full_unstemmed Does involucrin have a Role in Verruca Vulgaris? A Clinical and Immunohistochemical Study
title_short Does involucrin have a Role in Verruca Vulgaris? A Clinical and Immunohistochemical Study
title_sort does involucrin have a role in verruca vulgaris? a clinical and immunohistochemical study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751724/
https://www.ncbi.nlm.nih.gov/pubmed/35068499
http://dx.doi.org/10.4103/ijd.ijd_808_20
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