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Cutaneous Adverse Drug Reactions in a Tertiary Teaching Hospital: A Prospective, Observational Study

OBJECTIVE: To describe clinical patterns, identify associated drugs, and perform causality assessment of cutaneous adverse drug reactions. MATERIALS AND METHODS: In this prospective, observational study, patients with signs of cutaneous drug reaction from the department of dermatology of a tertiary...

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Autores principales: Jadhav, Anuja, Patil, Sharmila, Manchanda, Isheeta, Hasija, Ruchita, Patil, Anant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751732/
https://www.ncbi.nlm.nih.gov/pubmed/35068528
http://dx.doi.org/10.4103/ijd.ijd_874_20
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author Jadhav, Anuja
Patil, Sharmila
Manchanda, Isheeta
Hasija, Ruchita
Patil, Anant
author_facet Jadhav, Anuja
Patil, Sharmila
Manchanda, Isheeta
Hasija, Ruchita
Patil, Anant
author_sort Jadhav, Anuja
collection PubMed
description OBJECTIVE: To describe clinical patterns, identify associated drugs, and perform causality assessment of cutaneous adverse drug reactions. MATERIALS AND METHODS: In this prospective, observational study, patients with signs of cutaneous drug reaction from the department of dermatology of a tertiary teaching hospital were included. Patients with viral exanthemas were excluded. The patterns of cutaneous drug reactions, and associated drugs were noted. Naranjo scale was used for causality assessment of adverse drug reactions. RESULTS: Sixty-five patients (mean age 38.1 years) were included. Skin lesions were seen after 2 days of drug consumption in 25 (38.5%) patients. Pigmentation, fixed drug eruption, and maculo-papular rashes were seen in 13 (20%), 22 (33.8%), and 12 (18.5%) patients, respectively. Thirty-five (53.85%) patients had other associated symptoms. Fever was seen in 22 (33.8%) patients. Thirty-two (49.2%) cases had exposure to antibacterial agents. Most commonly associated drugs with reactions were nonsteroidal anti-inflammatory agents 14 (21.5%) followed by beta-lactam antibiotics 12 (18.5%), and fluroquinolones 7 (10.8%). Fifty-seven (87.7%) adverse drugs reactions had “probable” association with the drug.” CONCLUSION: Fixed drug eruption is the commonest presentation of cutaneous adverse drug reactions and antimicrobial agents are most commonly associated with it. According to the Naranjo scale, the majority of the cutaneous drug reactions have a “probable” association with the offending drugs.
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spelling pubmed-87517322022-01-21 Cutaneous Adverse Drug Reactions in a Tertiary Teaching Hospital: A Prospective, Observational Study Jadhav, Anuja Patil, Sharmila Manchanda, Isheeta Hasija, Ruchita Patil, Anant Indian J Dermatol Original Article OBJECTIVE: To describe clinical patterns, identify associated drugs, and perform causality assessment of cutaneous adverse drug reactions. MATERIALS AND METHODS: In this prospective, observational study, patients with signs of cutaneous drug reaction from the department of dermatology of a tertiary teaching hospital were included. Patients with viral exanthemas were excluded. The patterns of cutaneous drug reactions, and associated drugs were noted. Naranjo scale was used for causality assessment of adverse drug reactions. RESULTS: Sixty-five patients (mean age 38.1 years) were included. Skin lesions were seen after 2 days of drug consumption in 25 (38.5%) patients. Pigmentation, fixed drug eruption, and maculo-papular rashes were seen in 13 (20%), 22 (33.8%), and 12 (18.5%) patients, respectively. Thirty-five (53.85%) patients had other associated symptoms. Fever was seen in 22 (33.8%) patients. Thirty-two (49.2%) cases had exposure to antibacterial agents. Most commonly associated drugs with reactions were nonsteroidal anti-inflammatory agents 14 (21.5%) followed by beta-lactam antibiotics 12 (18.5%), and fluroquinolones 7 (10.8%). Fifty-seven (87.7%) adverse drugs reactions had “probable” association with the drug.” CONCLUSION: Fixed drug eruption is the commonest presentation of cutaneous adverse drug reactions and antimicrobial agents are most commonly associated with it. According to the Naranjo scale, the majority of the cutaneous drug reactions have a “probable” association with the offending drugs. Wolters Kluwer - Medknow 2021 /pmc/articles/PMC8751732/ /pubmed/35068528 http://dx.doi.org/10.4103/ijd.ijd_874_20 Text en Copyright: © 2021 Indian Journal of Dermatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Jadhav, Anuja
Patil, Sharmila
Manchanda, Isheeta
Hasija, Ruchita
Patil, Anant
Cutaneous Adverse Drug Reactions in a Tertiary Teaching Hospital: A Prospective, Observational Study
title Cutaneous Adverse Drug Reactions in a Tertiary Teaching Hospital: A Prospective, Observational Study
title_full Cutaneous Adverse Drug Reactions in a Tertiary Teaching Hospital: A Prospective, Observational Study
title_fullStr Cutaneous Adverse Drug Reactions in a Tertiary Teaching Hospital: A Prospective, Observational Study
title_full_unstemmed Cutaneous Adverse Drug Reactions in a Tertiary Teaching Hospital: A Prospective, Observational Study
title_short Cutaneous Adverse Drug Reactions in a Tertiary Teaching Hospital: A Prospective, Observational Study
title_sort cutaneous adverse drug reactions in a tertiary teaching hospital: a prospective, observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751732/
https://www.ncbi.nlm.nih.gov/pubmed/35068528
http://dx.doi.org/10.4103/ijd.ijd_874_20
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