Cargando…
Recurrent, Multisubtype Posttransplant Lymphoproliferative Disorder Masquerading as Inflammatory Bowel Disease
Posttransplant lymphoproliferative disorder (PTLD) is a severe posttransplant complication that occurs because of immunosuppression within the first year; however, recurrent PTLD or development of multiple histologic subtypes are rare. Our case demonstrates a renal transplant recipient with rare, re...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751774/ https://www.ncbi.nlm.nih.gov/pubmed/35028325 http://dx.doi.org/10.14309/crj.0000000000000734 |
_version_ | 1784631749019435008 |
---|---|
author | Mussarat, Saad Houston, Kevin V. Parekh, Parth J. |
author_facet | Mussarat, Saad Houston, Kevin V. Parekh, Parth J. |
author_sort | Mussarat, Saad |
collection | PubMed |
description | Posttransplant lymphoproliferative disorder (PTLD) is a severe posttransplant complication that occurs because of immunosuppression within the first year; however, recurrent PTLD or development of multiple histologic subtypes are rare. Our case demonstrates a renal transplant recipient with rare, recurrent PTLD with multiple histologic subtypes (monomorphic and polymorphic PTLD) despite a previous response to rituximab and resolution of inflammatory changes on endoscopy. It is essential that clinicians maintain a high suspicion for PTLD when caring for patients with previous transplantation and that they have a lower threshold for biopsy with endoscopic findings of nonspecific inflammatory changes. |
format | Online Article Text |
id | pubmed-8751774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-87517742022-01-12 Recurrent, Multisubtype Posttransplant Lymphoproliferative Disorder Masquerading as Inflammatory Bowel Disease Mussarat, Saad Houston, Kevin V. Parekh, Parth J. ACG Case Rep J Case Report Posttransplant lymphoproliferative disorder (PTLD) is a severe posttransplant complication that occurs because of immunosuppression within the first year; however, recurrent PTLD or development of multiple histologic subtypes are rare. Our case demonstrates a renal transplant recipient with rare, recurrent PTLD with multiple histologic subtypes (monomorphic and polymorphic PTLD) despite a previous response to rituximab and resolution of inflammatory changes on endoscopy. It is essential that clinicians maintain a high suspicion for PTLD when caring for patients with previous transplantation and that they have a lower threshold for biopsy with endoscopic findings of nonspecific inflammatory changes. Wolters Kluwer 2022-01-10 /pmc/articles/PMC8751774/ /pubmed/35028325 http://dx.doi.org/10.14309/crj.0000000000000734 Text en © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Case Report Mussarat, Saad Houston, Kevin V. Parekh, Parth J. Recurrent, Multisubtype Posttransplant Lymphoproliferative Disorder Masquerading as Inflammatory Bowel Disease |
title | Recurrent, Multisubtype Posttransplant Lymphoproliferative Disorder Masquerading as Inflammatory Bowel Disease |
title_full | Recurrent, Multisubtype Posttransplant Lymphoproliferative Disorder Masquerading as Inflammatory Bowel Disease |
title_fullStr | Recurrent, Multisubtype Posttransplant Lymphoproliferative Disorder Masquerading as Inflammatory Bowel Disease |
title_full_unstemmed | Recurrent, Multisubtype Posttransplant Lymphoproliferative Disorder Masquerading as Inflammatory Bowel Disease |
title_short | Recurrent, Multisubtype Posttransplant Lymphoproliferative Disorder Masquerading as Inflammatory Bowel Disease |
title_sort | recurrent, multisubtype posttransplant lymphoproliferative disorder masquerading as inflammatory bowel disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751774/ https://www.ncbi.nlm.nih.gov/pubmed/35028325 http://dx.doi.org/10.14309/crj.0000000000000734 |
work_keys_str_mv | AT mussaratsaad recurrentmultisubtypeposttransplantlymphoproliferativedisordermasqueradingasinflammatoryboweldisease AT houstonkevinv recurrentmultisubtypeposttransplantlymphoproliferativedisordermasqueradingasinflammatoryboweldisease AT parekhparthj recurrentmultisubtypeposttransplantlymphoproliferativedisordermasqueradingasinflammatoryboweldisease |