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Association Between Sleep Disturbances With Neurodevelopmental Problems and Decreased Health‐Related Quality of Life in Children With Fontan Circulation

BACKGROUND: Children with Fontan circulation are known to be at increased risk for neurodevelopmental problems and decreased health‐related quality of life (HRQOL), but many factors that may contribute to this risk are unknown. Sleep disturbances may be one previously unidentified factor that contri...

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Autores principales: Knobbe, Kirstin, Partha, Meghana, Seckeler, Michael D., Klewer, Scott, Hsu, Chiu‐Hsieh, Edgin, Jamie, Morgan, Wayne J., Provencio‐Dean, Natalie, Lopez, Silvia, Parthasarathy, Sairam, Combs, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751823/
https://www.ncbi.nlm.nih.gov/pubmed/34668394
http://dx.doi.org/10.1161/JAHA.121.021749
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author Knobbe, Kirstin
Partha, Meghana
Seckeler, Michael D.
Klewer, Scott
Hsu, Chiu‐Hsieh
Edgin, Jamie
Morgan, Wayne J.
Provencio‐Dean, Natalie
Lopez, Silvia
Parthasarathy, Sairam
Combs, Daniel
author_facet Knobbe, Kirstin
Partha, Meghana
Seckeler, Michael D.
Klewer, Scott
Hsu, Chiu‐Hsieh
Edgin, Jamie
Morgan, Wayne J.
Provencio‐Dean, Natalie
Lopez, Silvia
Parthasarathy, Sairam
Combs, Daniel
author_sort Knobbe, Kirstin
collection PubMed
description BACKGROUND: Children with Fontan circulation are known to be at increased risk for neurodevelopmental problems and decreased health‐related quality of life (HRQOL), but many factors that may contribute to this risk are unknown. Sleep disturbances may be one previously unidentified factor that contributes to this risk. METHODS AND RESULTS: We analyzed data from the Pediatric Heart Network Fontan cross‐sectional study to evaluate associations between a parent or child report of sleep disturbance with reported neurodevelopmental concerns and HRQOL in 558 children with Fontan circulation. Parent‐reported sleep disturbance was present in 11% of participants and child‐reported sleep disturbance was present in 15%. Parent‐reported sleep disturbance was associated with a significantly higher risk of attention problems, anxiety, depression, behavioral problems, and developmental delay (P<0.001 for all). Similarly, parent‐reported disturbance was associated with decreased HRQOL on both parent and child‐reported HRQOL (P<0.001 for most domains). Child‐reported sleep disturbances were associated with increased odds of anxiety, depression, and attention problems as well as worse HRQOL. These associations were present even after adjustment for cardiac, demographic, and socioeconomic factors that may affect HRQOL and neurodevelopmental status. CONCLUSIONS: Sleep disturbances in children with Fontan circulation are associated with an increased risk of neurodevelopmental problems as well as reduced HRQOL compared with those without sleep disturbance. Better understanding of sleep disturbances is needed in children with Fontan circulation, as sleep disturbances may represent a reversible cause of neurodevelopmental problems and decreased HRQOL in this population.
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spelling pubmed-87518232022-01-14 Association Between Sleep Disturbances With Neurodevelopmental Problems and Decreased Health‐Related Quality of Life in Children With Fontan Circulation Knobbe, Kirstin Partha, Meghana Seckeler, Michael D. Klewer, Scott Hsu, Chiu‐Hsieh Edgin, Jamie Morgan, Wayne J. Provencio‐Dean, Natalie Lopez, Silvia Parthasarathy, Sairam Combs, Daniel J Am Heart Assoc Original Research BACKGROUND: Children with Fontan circulation are known to be at increased risk for neurodevelopmental problems and decreased health‐related quality of life (HRQOL), but many factors that may contribute to this risk are unknown. Sleep disturbances may be one previously unidentified factor that contributes to this risk. METHODS AND RESULTS: We analyzed data from the Pediatric Heart Network Fontan cross‐sectional study to evaluate associations between a parent or child report of sleep disturbance with reported neurodevelopmental concerns and HRQOL in 558 children with Fontan circulation. Parent‐reported sleep disturbance was present in 11% of participants and child‐reported sleep disturbance was present in 15%. Parent‐reported sleep disturbance was associated with a significantly higher risk of attention problems, anxiety, depression, behavioral problems, and developmental delay (P<0.001 for all). Similarly, parent‐reported disturbance was associated with decreased HRQOL on both parent and child‐reported HRQOL (P<0.001 for most domains). Child‐reported sleep disturbances were associated with increased odds of anxiety, depression, and attention problems as well as worse HRQOL. These associations were present even after adjustment for cardiac, demographic, and socioeconomic factors that may affect HRQOL and neurodevelopmental status. CONCLUSIONS: Sleep disturbances in children with Fontan circulation are associated with an increased risk of neurodevelopmental problems as well as reduced HRQOL compared with those without sleep disturbance. Better understanding of sleep disturbances is needed in children with Fontan circulation, as sleep disturbances may represent a reversible cause of neurodevelopmental problems and decreased HRQOL in this population. John Wiley and Sons Inc. 2021-10-20 /pmc/articles/PMC8751823/ /pubmed/34668394 http://dx.doi.org/10.1161/JAHA.121.021749 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Knobbe, Kirstin
Partha, Meghana
Seckeler, Michael D.
Klewer, Scott
Hsu, Chiu‐Hsieh
Edgin, Jamie
Morgan, Wayne J.
Provencio‐Dean, Natalie
Lopez, Silvia
Parthasarathy, Sairam
Combs, Daniel
Association Between Sleep Disturbances With Neurodevelopmental Problems and Decreased Health‐Related Quality of Life in Children With Fontan Circulation
title Association Between Sleep Disturbances With Neurodevelopmental Problems and Decreased Health‐Related Quality of Life in Children With Fontan Circulation
title_full Association Between Sleep Disturbances With Neurodevelopmental Problems and Decreased Health‐Related Quality of Life in Children With Fontan Circulation
title_fullStr Association Between Sleep Disturbances With Neurodevelopmental Problems and Decreased Health‐Related Quality of Life in Children With Fontan Circulation
title_full_unstemmed Association Between Sleep Disturbances With Neurodevelopmental Problems and Decreased Health‐Related Quality of Life in Children With Fontan Circulation
title_short Association Between Sleep Disturbances With Neurodevelopmental Problems and Decreased Health‐Related Quality of Life in Children With Fontan Circulation
title_sort association between sleep disturbances with neurodevelopmental problems and decreased health‐related quality of life in children with fontan circulation
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751823/
https://www.ncbi.nlm.nih.gov/pubmed/34668394
http://dx.doi.org/10.1161/JAHA.121.021749
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