The Emerging Role of Irisin in Cardiovascular Diseases

Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein 5). The current knowledge on the biological functions of irisin includes browning white adipose tissue, regulating insulin...

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Detalles Bibliográficos
Autores principales: Fu, Jinjuan, Li, Fangtang, Tang, Yuanjuan, Cai, Lin, Zeng, Chunyu, Yang, Yongjian, Yang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Contemporary Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751904/
https://www.ncbi.nlm.nih.gov/pubmed/34622672
http://dx.doi.org/10.1161/JAHA.121.022453
Descripción
Sumario:Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein 5). The current knowledge on the biological functions of irisin includes browning white adipose tissue, regulating insulin use, and anti‐inflammatory and antioxidative properties. Dysfunction of irisin has shown to be involved in cardiovascular diseases such as hypertension, coronary artery disease, myocardial infarction, and myocardial ischemia–reperfusion injury. Moreover, irisin gene variants are also associated with cardiovascular diseases. In this review, we discuss the current knowledge on irisin‐mediated regulatory mechanisms and their roles in the pathogenesis of cardiovascular diseases.

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