The Emerging Role of Irisin in Cardiovascular Diseases

Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein 5). The current knowledge on the biological functions of irisin includes browning white adipose tissue, regulating insulin...

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Detalles Bibliográficos
Autores principales: Fu, Jinjuan, Li, Fangtang, Tang, Yuanjuan, Cai, Lin, Zeng, Chunyu, Yang, Yongjian, Yang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Contemporary Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751904/
https://www.ncbi.nlm.nih.gov/pubmed/34622672
http://dx.doi.org/10.1161/JAHA.121.022453
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author Fu, Jinjuan
Li, Fangtang
Tang, Yuanjuan
Cai, Lin
Zeng, Chunyu
Yang, Yongjian
Yang, Jian
author_facet Fu, Jinjuan
Li, Fangtang
Tang, Yuanjuan
Cai, Lin
Zeng, Chunyu
Yang, Yongjian
Yang, Jian
author_sort Fu, Jinjuan
collection PubMed
description Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein 5). The current knowledge on the biological functions of irisin includes browning white adipose tissue, regulating insulin use, and anti‐inflammatory and antioxidative properties. Dysfunction of irisin has shown to be involved in cardiovascular diseases such as hypertension, coronary artery disease, myocardial infarction, and myocardial ischemia–reperfusion injury. Moreover, irisin gene variants are also associated with cardiovascular diseases. In this review, we discuss the current knowledge on irisin‐mediated regulatory mechanisms and their roles in the pathogenesis of cardiovascular diseases.
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spelling pubmed-87519042022-01-14 The Emerging Role of Irisin in Cardiovascular Diseases Fu, Jinjuan Li, Fangtang Tang, Yuanjuan Cai, Lin Zeng, Chunyu Yang, Yongjian Yang, Jian J Am Heart Assoc Contemporary Review Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein 5). The current knowledge on the biological functions of irisin includes browning white adipose tissue, regulating insulin use, and anti‐inflammatory and antioxidative properties. Dysfunction of irisin has shown to be involved in cardiovascular diseases such as hypertension, coronary artery disease, myocardial infarction, and myocardial ischemia–reperfusion injury. Moreover, irisin gene variants are also associated with cardiovascular diseases. In this review, we discuss the current knowledge on irisin‐mediated regulatory mechanisms and their roles in the pathogenesis of cardiovascular diseases. John Wiley and Sons Inc. 2021-10-08 /pmc/articles/PMC8751904/ /pubmed/34622672 http://dx.doi.org/10.1161/JAHA.121.022453 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Contemporary Review
Fu, Jinjuan
Li, Fangtang
Tang, Yuanjuan
Cai, Lin
Zeng, Chunyu
Yang, Yongjian
Yang, Jian
The Emerging Role of Irisin in Cardiovascular Diseases
title The Emerging Role of Irisin in Cardiovascular Diseases
title_full The Emerging Role of Irisin in Cardiovascular Diseases
title_fullStr The Emerging Role of Irisin in Cardiovascular Diseases
title_full_unstemmed The Emerging Role of Irisin in Cardiovascular Diseases
title_short The Emerging Role of Irisin in Cardiovascular Diseases
title_sort emerging role of irisin in cardiovascular diseases
topic Contemporary Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751904/
https://www.ncbi.nlm.nih.gov/pubmed/34622672
http://dx.doi.org/10.1161/JAHA.121.022453
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