Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’

Early in the SARS-CoV-2 pandemic, we compared transcriptome data from hospitalized COVID-19 patients and control patients without COVID-19. We found changes in procoagulant and fibrinolytic gene expression in the lungs of COVID-19 patients (Mast et al., 2021). These findings have been challenged bas...

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Autores principales: Mast, Alan E, Wolberg, Alisa S, Gailani, David, Garvin, Michael R, Alvarez, Christiane, Miller, J Izaak, Jones, Piet, Aronow, Bruce, Jacobson, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752086/
https://www.ncbi.nlm.nih.gov/pubmed/35014952
http://dx.doi.org/10.7554/eLife.74951
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author Mast, Alan E
Wolberg, Alisa S
Gailani, David
Garvin, Michael R
Alvarez, Christiane
Miller, J Izaak
Jones, Piet
Aronow, Bruce
Jacobson, Daniel
author_facet Mast, Alan E
Wolberg, Alisa S
Gailani, David
Garvin, Michael R
Alvarez, Christiane
Miller, J Izaak
Jones, Piet
Aronow, Bruce
Jacobson, Daniel
author_sort Mast, Alan E
collection PubMed
description Early in the SARS-CoV-2 pandemic, we compared transcriptome data from hospitalized COVID-19 patients and control patients without COVID-19. We found changes in procoagulant and fibrinolytic gene expression in the lungs of COVID-19 patients (Mast et al., 2021). These findings have been challenged based on issues with the samples (Fitzgerald and Jamieson, 2022). We have revisited our previous analyses in the light of this challenge and find that these new analyses support our original conclusions.
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spelling pubmed-87520862022-01-12 Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’ Mast, Alan E Wolberg, Alisa S Gailani, David Garvin, Michael R Alvarez, Christiane Miller, J Izaak Jones, Piet Aronow, Bruce Jacobson, Daniel eLife Computational and Systems Biology Early in the SARS-CoV-2 pandemic, we compared transcriptome data from hospitalized COVID-19 patients and control patients without COVID-19. We found changes in procoagulant and fibrinolytic gene expression in the lungs of COVID-19 patients (Mast et al., 2021). These findings have been challenged based on issues with the samples (Fitzgerald and Jamieson, 2022). We have revisited our previous analyses in the light of this challenge and find that these new analyses support our original conclusions. eLife Sciences Publications, Ltd 2022-01-11 /pmc/articles/PMC8752086/ /pubmed/35014952 http://dx.doi.org/10.7554/eLife.74951 Text en © 2022, Mast et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Computational and Systems Biology
Mast, Alan E
Wolberg, Alisa S
Gailani, David
Garvin, Michael R
Alvarez, Christiane
Miller, J Izaak
Jones, Piet
Aronow, Bruce
Jacobson, Daniel
Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’
title Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’
title_full Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’
title_fullStr Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’
title_full_unstemmed Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’
title_short Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’
title_sort response to comment on ‘sars-cov-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’
topic Computational and Systems Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752086/
https://www.ncbi.nlm.nih.gov/pubmed/35014952
http://dx.doi.org/10.7554/eLife.74951
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