Will 14-3-3η Be a New Diagnostic and Prognostic Biomarker in Rheumatoid Arthritis? A Prospective Study of Its Utility in Early Diagnosis and Response to Treatment

RESULTS: Serum14-3-3η levels were significantly higher in all RA patients than in controls (P < 0.001), its sensitivity was 86.7% and 88.3% in early and established RA patients with a significant difference with RF and ACCP at early disease, and the specificity was 96.7%. There was a significant...

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Autores principales: Alashkar, Doaa Shawky, Elkhouly, Radwa Mostafa, Abd Elnaby, Amira Yousef, Nada, Doaa Waseem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752307/
https://www.ncbi.nlm.nih.gov/pubmed/35028161
http://dx.doi.org/10.1155/2022/1497748
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author Alashkar, Doaa Shawky
Elkhouly, Radwa Mostafa
Abd Elnaby, Amira Yousef
Nada, Doaa Waseem
author_facet Alashkar, Doaa Shawky
Elkhouly, Radwa Mostafa
Abd Elnaby, Amira Yousef
Nada, Doaa Waseem
author_sort Alashkar, Doaa Shawky
collection PubMed
description RESULTS: Serum14-3-3η levels were significantly higher in all RA patients than in controls (P < 0.001), its sensitivity was 86.7% and 88.3% in early and established RA patients with a significant difference with RF and ACCP at early disease, and the specificity was 96.7%. There was a significant reduction of 14-3-3η levels 6 months after treatment in the first group (p=0.004), and there was a significant positive correlation between serum 14-3-3η levels and parameters of disease activity and severity. CONCLUSION: 14-3-3η could be a novel, potent, and efficacious diagnostic, and prognostic marker for RA with high sensitivity, that may become a new therapeutic target for RA.
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spelling pubmed-87523072022-01-12 Will 14-3-3η Be a New Diagnostic and Prognostic Biomarker in Rheumatoid Arthritis? A Prospective Study of Its Utility in Early Diagnosis and Response to Treatment Alashkar, Doaa Shawky Elkhouly, Radwa Mostafa Abd Elnaby, Amira Yousef Nada, Doaa Waseem Autoimmune Dis Research Article RESULTS: Serum14-3-3η levels were significantly higher in all RA patients than in controls (P < 0.001), its sensitivity was 86.7% and 88.3% in early and established RA patients with a significant difference with RF and ACCP at early disease, and the specificity was 96.7%. There was a significant reduction of 14-3-3η levels 6 months after treatment in the first group (p=0.004), and there was a significant positive correlation between serum 14-3-3η levels and parameters of disease activity and severity. CONCLUSION: 14-3-3η could be a novel, potent, and efficacious diagnostic, and prognostic marker for RA with high sensitivity, that may become a new therapeutic target for RA. Hindawi 2022-01-04 /pmc/articles/PMC8752307/ /pubmed/35028161 http://dx.doi.org/10.1155/2022/1497748 Text en Copyright © 2022 Doaa Shawky Alashkar et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Alashkar, Doaa Shawky
Elkhouly, Radwa Mostafa
Abd Elnaby, Amira Yousef
Nada, Doaa Waseem
Will 14-3-3η Be a New Diagnostic and Prognostic Biomarker in Rheumatoid Arthritis? A Prospective Study of Its Utility in Early Diagnosis and Response to Treatment
title Will 14-3-3η Be a New Diagnostic and Prognostic Biomarker in Rheumatoid Arthritis? A Prospective Study of Its Utility in Early Diagnosis and Response to Treatment
title_full Will 14-3-3η Be a New Diagnostic and Prognostic Biomarker in Rheumatoid Arthritis? A Prospective Study of Its Utility in Early Diagnosis and Response to Treatment
title_fullStr Will 14-3-3η Be a New Diagnostic and Prognostic Biomarker in Rheumatoid Arthritis? A Prospective Study of Its Utility in Early Diagnosis and Response to Treatment
title_full_unstemmed Will 14-3-3η Be a New Diagnostic and Prognostic Biomarker in Rheumatoid Arthritis? A Prospective Study of Its Utility in Early Diagnosis and Response to Treatment
title_short Will 14-3-3η Be a New Diagnostic and Prognostic Biomarker in Rheumatoid Arthritis? A Prospective Study of Its Utility in Early Diagnosis and Response to Treatment
title_sort will 14-3-3η be a new diagnostic and prognostic biomarker in rheumatoid arthritis? a prospective study of its utility in early diagnosis and response to treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752307/
https://www.ncbi.nlm.nih.gov/pubmed/35028161
http://dx.doi.org/10.1155/2022/1497748
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