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Interpreting Potts and Transformer Protein Models Through the Lens of Simplified Attention
The established approach to unsupervised protein contact prediction estimates coevolving positions using undirected graphical models. This approach trains a Potts model on a Multiple Sequence Alignment. Increasingly large Transformers are being pretrained on unlabeled, unaligned protein sequence dat...
Autores principales: | Bhattacharya, Nicholas, Thomas, Neil, Rao, Roshan, Dauparas, Justas, Koo, Peter K., Baker, David, Song, Yun S., Ovchinnikov, Sergey |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752338/ https://www.ncbi.nlm.nih.gov/pubmed/34890134 |
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