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A Locally Aggressive Ameloblastic Fibro-Odontoma: A Case Report and Literature Review

Ameloblastic fibro-odontoma (AFO) is a relatively rare, benign noninvasive mixed odontogenic neoplasm derived from epithelial and ectomesenchymal elements of the dental tissues. It usually presents with a mean age of 11.5 years and in the posterior segment of the mandible. It is extremely rare in th...

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Autores principales: Omar, Nivin, Ullah, Asad, Ghleilib, Intisar, Patel, Nikhil, Abdelsayed, Rafik A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752350/
https://www.ncbi.nlm.nih.gov/pubmed/35036200
http://dx.doi.org/10.7759/cureus.20366
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author Omar, Nivin
Ullah, Asad
Ghleilib, Intisar
Patel, Nikhil
Abdelsayed, Rafik A
author_facet Omar, Nivin
Ullah, Asad
Ghleilib, Intisar
Patel, Nikhil
Abdelsayed, Rafik A
author_sort Omar, Nivin
collection PubMed
description Ameloblastic fibro-odontoma (AFO) is a relatively rare, benign noninvasive mixed odontogenic neoplasm derived from epithelial and ectomesenchymal elements of the dental tissues. It usually presents with a mean age of 11.5 years and in the posterior segment of the mandible. It is extremely rare in the posterior maxilla. Although the latest WHO edition classified AFO as developing odontoma, here we present a locally aggressive AFO in a 21-year-old male involving the posterior maxilla and sinus with bone destruction. The patient presents with a two-year history of slowly progressive left facial swelling with malodorous drainage. The CT scan revealed a 5.5 x 4.3 cm well-circumscribed expansile mass with mixed attenuation and peripheral calcification occupying the left maxilla and sinus with bone destruction of the hard palate and orbital rim. According to the literature, most of the AFO cases were treated adequately through a conservative approach with just enucleation or surgical curettage. To our knowledge, our case is the first case treated aggressively with left maxillectomy, palatectomy, and reconstruction surgery because of its radiologic findings, which suggested a locally invasive neoplasm. Histologically, the specimen showed a mixture of proliferative epithelial, mesenchymal tissue elements, and variable amounts of mineralized deposits consisting of enamel matrix and dentinoid deposits, and the final diagnosis was AFO. In conclusion, we present a rare case of AFO with an unusual aggressive presentation, age group, and site involved. The radiographic, histopathologic features, and therapeutic approaches of this unusual locally aggressive tumor are presented with the review of relevant literature.
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spelling pubmed-87523502022-01-14 A Locally Aggressive Ameloblastic Fibro-Odontoma: A Case Report and Literature Review Omar, Nivin Ullah, Asad Ghleilib, Intisar Patel, Nikhil Abdelsayed, Rafik A Cureus Pathology Ameloblastic fibro-odontoma (AFO) is a relatively rare, benign noninvasive mixed odontogenic neoplasm derived from epithelial and ectomesenchymal elements of the dental tissues. It usually presents with a mean age of 11.5 years and in the posterior segment of the mandible. It is extremely rare in the posterior maxilla. Although the latest WHO edition classified AFO as developing odontoma, here we present a locally aggressive AFO in a 21-year-old male involving the posterior maxilla and sinus with bone destruction. The patient presents with a two-year history of slowly progressive left facial swelling with malodorous drainage. The CT scan revealed a 5.5 x 4.3 cm well-circumscribed expansile mass with mixed attenuation and peripheral calcification occupying the left maxilla and sinus with bone destruction of the hard palate and orbital rim. According to the literature, most of the AFO cases were treated adequately through a conservative approach with just enucleation or surgical curettage. To our knowledge, our case is the first case treated aggressively with left maxillectomy, palatectomy, and reconstruction surgery because of its radiologic findings, which suggested a locally invasive neoplasm. Histologically, the specimen showed a mixture of proliferative epithelial, mesenchymal tissue elements, and variable amounts of mineralized deposits consisting of enamel matrix and dentinoid deposits, and the final diagnosis was AFO. In conclusion, we present a rare case of AFO with an unusual aggressive presentation, age group, and site involved. The radiographic, histopathologic features, and therapeutic approaches of this unusual locally aggressive tumor are presented with the review of relevant literature. Cureus 2021-12-12 /pmc/articles/PMC8752350/ /pubmed/35036200 http://dx.doi.org/10.7759/cureus.20366 Text en Copyright © 2021, Omar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Omar, Nivin
Ullah, Asad
Ghleilib, Intisar
Patel, Nikhil
Abdelsayed, Rafik A
A Locally Aggressive Ameloblastic Fibro-Odontoma: A Case Report and Literature Review
title A Locally Aggressive Ameloblastic Fibro-Odontoma: A Case Report and Literature Review
title_full A Locally Aggressive Ameloblastic Fibro-Odontoma: A Case Report and Literature Review
title_fullStr A Locally Aggressive Ameloblastic Fibro-Odontoma: A Case Report and Literature Review
title_full_unstemmed A Locally Aggressive Ameloblastic Fibro-Odontoma: A Case Report and Literature Review
title_short A Locally Aggressive Ameloblastic Fibro-Odontoma: A Case Report and Literature Review
title_sort locally aggressive ameloblastic fibro-odontoma: a case report and literature review
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752350/
https://www.ncbi.nlm.nih.gov/pubmed/35036200
http://dx.doi.org/10.7759/cureus.20366
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