Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation

AIMS : Dilated cardiomyopathy (DCM) is associated with mutations in many genes encoding sarcomere proteins. Truncating mutations in the titin gene TTN are the most frequent. Proteomic and functional characterizations are required to elucidate the origin of the disease and the pathogenic mechanisms o...

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Detalles Bibliográficos
Autores principales: Vikhorev, Petr G, Vikhoreva, Natalia N, Yeung, WaiChun, Li, Amy, Lal, Sean, dos Remedios, Cristobal G, Blair, Cheavar A, Guglin, Maya, Campbell, Kenneth S, Yacoub, Magdi H, de Tombe, Pieter, Marston, Steven B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752363/
https://www.ncbi.nlm.nih.gov/pubmed/33135063
http://dx.doi.org/10.1093/cvr/cvaa316

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