Cargando…

Whole‐blood cytokine secretion assay as a high‐throughput alternative for assessing the cell‐mediated immunity profile after two doses of an adjuvanted SARS‐CoV‐2 recombinant protein vaccine candidate

OBJECTIVES: We previously described the Phase I‐II evaluation of SARS‐CoV‐2 recombinant protein candidate vaccine, CoV2‐PreS‐dTM, with AF03‐ or AS03‐adjuvant systems (ClinicalTrials.gov, NCT04537208). Here, we further characterise the cellular immunogenicity profile of this vaccine candidate using a...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Rosa, Stephen C, Cohen, Kristen W, Bonaparte, Matthew, Fu, Bo, Garg, Sanjay, Gerard, Catherine, Goepfert, Paul A, Huang, Ying, Larocque, Daniel, McElrath, M. Juliana, Morris, Daryl, Van der Most, Robbert, de Bruyn, Guy, Pagnon, Anke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752373/ https://www.ncbi.nlm.nih.gov/pubmed/35035955 http://dx.doi.org/10.1002/cti2.1360

Ejemplares similares

Pre-Existing Adenovirus Immunity Modifies a Complex Mixed Th1 and Th2 Cytokine Response to an Ad5/HIV-1 Vaccine Candidate in Humans
por: Pine, Samuel O., et al.
Publicado: (2011)

Profiles of Human Serum Antibody Responses Elicited by Three Leading HIV Vaccines Focusing on the Induction of Env-Specific Antibodies
por: Vaine, Michael, et al.
Publicado: (2010)

OMIP‐056: Evaluation of Human Conventional T Cells, Donor‐Unrestricted T Cells, and NK Cells Including Memory Phenotype by Intracellular Cytokine Staining
por: Dintwe, One, et al.
Publicado: (2019)

Machine learning identifies molecular regulators and therapeutics for targeting SARS‐CoV2‐induced cytokine release
por: Chan, Marina, et al.
Publicado: (2021)

Adjuvant-Associated Peripheral Blood mRNA Profiles and Kinetics Induced by the Adjuvanted Recombinant Protein Candidate Tuberculosis Vaccine M72/AS01 in Bacillus Calmette–Guérin-Vaccinated Adults
por: van den Berg, Robert A., et al.
Publicado: (2018)

Characterization of T-cell immune responses in clinical trials of the candidate RTS,S malaria vaccine
por: Moris, Philippe, et al.
Publicado: (2017)

Emergent Electroweak Gravity
por: McElrath, Bob
Publicado: (2008)

Laboratory tests for the cosmic neutrino background using beta-decaying nuclei
por: McElrath, Bob
Publicado: (2009)

On The Origin of Neutrino Mass and Mixing in the Standard Model
por: McElrath, Bob
Publicado: (2009)

“World in motion” – emulsion adjuvants rising to meet the pandemic challenges
por: O’Hagan, Derek T., et al.
Publicado: (2021)

$h \to \mu^{+}\mu^{-}$ via Gluon Fusion at the LHC
por: Han, T, et al.
Publicado: (2002)

Generation of a cost-effective cell line for support of high-throughput isolation of primary human B cells and monoclonal neutralizing antibodies
por: Whaley, Rachael E., et al.
Publicado: (2021)

Author Correction: “World in motion” – emulsion adjuvants rising to meet the pandemic challenges
por: O’Hagan, Derek T., et al.
Publicado: (2023)

Use of adenovirus type-5 vectored vaccines: a cautionary tale
por: Buchbinder, Susan P, et al.
Publicado: (2020)

COVID-19 vaccination and HIV-1 acquisition – Authors’ reply
por: Buchbinder, Susan P, et al.
Publicado: (2022)

Vaccination with MVA/HIV induces differential recruitment of monocyte subsets into the circulation and monocyte-specific transcriptional programs
por: Andersen-Nissen, E, et al.
Publicado: (2012)

There is no explosion risk associated with superfluid Helium in the LHC cooling system
por: Fairbairn, Malcolm, et al.
Publicado: (2008)

Humoral and cellular immunogenicity and safety following a booster dose of a tetravalent dengue vaccine 5+ years after completion of the primary series in Singapore: 2-year follow-up of a randomized phase II, placebo-controlled trial
por: Park, Juliana, et al.
Publicado: (2021)

Cytokine Profile of Children Hospitalized with Virologically-Confirmed Dengue during Two Phase III Vaccine Efficacy Trials
por: Harenberg, Anke, et al.
Publicado: (2016)

MRKAd5 HIV-1 Gag/Pol/Nef Vaccine-Induced T-Cell Responses Inadequately Predict Distance of Breakthrough HIV-1 Sequences to the Vaccine or Viral Load
por: Janes, Holly, et al.
Publicado: (2012)

A Novel HIV Vaccine Adjuvanted by IC31 Induces Robust and Persistent Humoral and Cellular Immunity
por: Pattacini, Laura, et al.
Publicado: (2012)

Winning grants step by step: the complete workbook for planning, developing, and writing successful proposals
por: O'Neal-McElrath, Tori, et al.
Publicado: (2013)

Use of B-Cell–Depleting Therapy in Women of Childbearing Potential With Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
por: Galati, Alexandra, et al.
Publicado: (2022)

HIV-1 Induces Cytotoxic T Lymphocytes in the Cervix of Infected Women
por: Musey, Luwy, et al.
Publicado: (1997)

CXCR3 enables recruitment and site-specific bystander activation of memory CD8(+) T cells
por: Maurice, Nicholas J., et al.
Publicado: (2019)

Subsequent AS01-adjuvanted vaccinations induce similar transcriptional responses in populations with different disease statuses
por: Coccia, Margherita, et al.
Publicado: (2022)

Impact of adjuvants on the biophysical and functional characteristics of HIV vaccine-elicited antibodies in humans
por: Xu, Shiwei, et al.
Publicado: (2022)

Cell Recruitment and Cytokines in Skin Mice Sensitized with the Vaccine Adjuvants: Saponin, Incomplete Freund’s Adjuvant, and Monophosphoryl Lipid A
por: Vitoriano-Souza, Juliana, et al.
Publicado: (2012)

P17-25. A model for coverage of T-cell HIV vaccines: where are we and where do we need to be?
por: Self, S, et al.
Publicado: (2009)

Little Higgs models
por: Grégoire, Thomas, et al.
Publicado: (2006)

Signatures of Extra Dimensions from Upsilon Decays with a Light Gaugephobic Higgs Boson
por: Galloway, Jamison, et al.
Publicado: (2008)

Black–White Disparities in Criminal Justice Referrals to Drug Treatment: Addressing Treatment Need or Expanding the Diagnostic Net?
por: McElrath, Karen, et al.
Publicado: (2016)

Prevalence of High-Intensity Drinking from Adolescence through Young Adulthood: National Data from 2016-2017
por: Patrick, Megan E, et al.
Publicado: (2019)

Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection
por: Liu, Yi, et al.
Publicado: (2011)

A FluoroSpot B assay for the detection of IgA and IgG SARS-CoV-2 spike-specific memory B cells: Optimization and qualification for use in COVID-19 vaccine trials
por: Bisceglia, Hélène, et al.
Publicado: (2023)

Cytokines: The Future of Intranasal Vaccine Adjuvants
por: Thompson, Afton L., et al.
Publicado: (2011)

Initial Events in Establishing Vaginal Entry and Infection by Human Immunodeficiency Virus Type-1
por: Hladik, Florian, et al.
Publicado: (2007)

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial Reveals an Association of Nonspecific Interferon-γ Secretion with Increased HIV-1 Infection Risk: A Cohort-Based Modeling Study
por: Huang, Yunda, et al.
Publicado: (2014)

Measuring Neutrino Mass with Radioactive Ions in a Storage Ring
por: Lindroos, Mats, et al.
Publicado: (2010)

Measuring neutrino mass with radioactive ions in a storage ring
por: Lindroos, Mats, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_vkvo8njng183tf2329bac2ni5v