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The incidence of COVID-19 infection following emergency use authorization of BBIBP-CORV inactivated vaccine in frontline workers in the United Arab Emirates
Based on the findings from the Phase III clinical trials of inactivated SARS COV-2 Vaccine, (BBIBP-CORV) emergency use authorization (EUA) was granted for the vaccine to frontline workers in the UAE. A prospective cohort study was conducted among frontline workers to estimate the incidence rate and...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752587/ https://www.ncbi.nlm.nih.gov/pubmed/35017530 http://dx.doi.org/10.1038/s41598-021-04244-1 |
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author | Al Kaabi, Nawal Oulhaj, Abderrahim Al Hosani, Farida Ismail Al Mazrouei, Shamma Najim, Omer Hussein, Salah Eldin Abdalla, Jehad Saleh Fasihuddin, Mohammed Saifuddin Hassan, Afnan Abdellatif Elghazali, Gehad Al Rumaithi, Ahmed Al Azazi, Jumana Weber, Stefan Beiram, Rami Parekh, Khatija A. Sheek-Hussein, Mohamud Yang, Yunkai Xiaoming, Yang Quliang, Jenny Eltantawy, Islam Mahmoud, Sally Koshy, Ashish Xiao, Peng Ganesan, Subhashini Elamin, Wael Zaher, Walid |
author_facet | Al Kaabi, Nawal Oulhaj, Abderrahim Al Hosani, Farida Ismail Al Mazrouei, Shamma Najim, Omer Hussein, Salah Eldin Abdalla, Jehad Saleh Fasihuddin, Mohammed Saifuddin Hassan, Afnan Abdellatif Elghazali, Gehad Al Rumaithi, Ahmed Al Azazi, Jumana Weber, Stefan Beiram, Rami Parekh, Khatija A. Sheek-Hussein, Mohamud Yang, Yunkai Xiaoming, Yang Quliang, Jenny Eltantawy, Islam Mahmoud, Sally Koshy, Ashish Xiao, Peng Ganesan, Subhashini Elamin, Wael Zaher, Walid |
author_sort | Al Kaabi, Nawal |
collection | PubMed |
description | Based on the findings from the Phase III clinical trials of inactivated SARS COV-2 Vaccine, (BBIBP-CORV) emergency use authorization (EUA) was granted for the vaccine to frontline workers in the UAE. A prospective cohort study was conducted among frontline workers to estimate the incidence rate and risk of symptomatic COVID-19 infection 14 days after the second dose of inoculation with BBIBP-CORV inactivated vaccine. Those who received two doses of the BBIBP-CORV vaccine in the period from 14th of September 2020 (first dose) to 21st of December 2020 (second dose) were followed up for COVID-19 infections. 11,322 individuals who received the two-dose BBIBP-CORV vaccine were included and were followed up post the second dose plus fourteen days. The incidence rate of symptomatic infection was 0.08 per 1000-person days (95% CI 0.07, 0.10). The estimated absolute risk of developing symptomatic infection was 0.97% (95% CI 0.77%, 1.17%). The confirmed seroconversion rate was 92.8%. There were no serious adverse events reported and no individuals suffered from severe disease. Our findings show that vaccinated individuals are likely to remain protected against symptomatic infection or becoming PCR positive for SARS COV 2 following the second dose of the vaccination. |
format | Online Article Text |
id | pubmed-8752587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-87525872022-01-13 The incidence of COVID-19 infection following emergency use authorization of BBIBP-CORV inactivated vaccine in frontline workers in the United Arab Emirates Al Kaabi, Nawal Oulhaj, Abderrahim Al Hosani, Farida Ismail Al Mazrouei, Shamma Najim, Omer Hussein, Salah Eldin Abdalla, Jehad Saleh Fasihuddin, Mohammed Saifuddin Hassan, Afnan Abdellatif Elghazali, Gehad Al Rumaithi, Ahmed Al Azazi, Jumana Weber, Stefan Beiram, Rami Parekh, Khatija A. Sheek-Hussein, Mohamud Yang, Yunkai Xiaoming, Yang Quliang, Jenny Eltantawy, Islam Mahmoud, Sally Koshy, Ashish Xiao, Peng Ganesan, Subhashini Elamin, Wael Zaher, Walid Sci Rep Article Based on the findings from the Phase III clinical trials of inactivated SARS COV-2 Vaccine, (BBIBP-CORV) emergency use authorization (EUA) was granted for the vaccine to frontline workers in the UAE. A prospective cohort study was conducted among frontline workers to estimate the incidence rate and risk of symptomatic COVID-19 infection 14 days after the second dose of inoculation with BBIBP-CORV inactivated vaccine. Those who received two doses of the BBIBP-CORV vaccine in the period from 14th of September 2020 (first dose) to 21st of December 2020 (second dose) were followed up for COVID-19 infections. 11,322 individuals who received the two-dose BBIBP-CORV vaccine were included and were followed up post the second dose plus fourteen days. The incidence rate of symptomatic infection was 0.08 per 1000-person days (95% CI 0.07, 0.10). The estimated absolute risk of developing symptomatic infection was 0.97% (95% CI 0.77%, 1.17%). The confirmed seroconversion rate was 92.8%. There were no serious adverse events reported and no individuals suffered from severe disease. Our findings show that vaccinated individuals are likely to remain protected against symptomatic infection or becoming PCR positive for SARS COV 2 following the second dose of the vaccination. Nature Publishing Group UK 2022-01-11 /pmc/articles/PMC8752587/ /pubmed/35017530 http://dx.doi.org/10.1038/s41598-021-04244-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Al Kaabi, Nawal Oulhaj, Abderrahim Al Hosani, Farida Ismail Al Mazrouei, Shamma Najim, Omer Hussein, Salah Eldin Abdalla, Jehad Saleh Fasihuddin, Mohammed Saifuddin Hassan, Afnan Abdellatif Elghazali, Gehad Al Rumaithi, Ahmed Al Azazi, Jumana Weber, Stefan Beiram, Rami Parekh, Khatija A. Sheek-Hussein, Mohamud Yang, Yunkai Xiaoming, Yang Quliang, Jenny Eltantawy, Islam Mahmoud, Sally Koshy, Ashish Xiao, Peng Ganesan, Subhashini Elamin, Wael Zaher, Walid The incidence of COVID-19 infection following emergency use authorization of BBIBP-CORV inactivated vaccine in frontline workers in the United Arab Emirates |
title | The incidence of COVID-19 infection following emergency use authorization of BBIBP-CORV inactivated vaccine in frontline workers in the United Arab Emirates |
title_full | The incidence of COVID-19 infection following emergency use authorization of BBIBP-CORV inactivated vaccine in frontline workers in the United Arab Emirates |
title_fullStr | The incidence of COVID-19 infection following emergency use authorization of BBIBP-CORV inactivated vaccine in frontline workers in the United Arab Emirates |
title_full_unstemmed | The incidence of COVID-19 infection following emergency use authorization of BBIBP-CORV inactivated vaccine in frontline workers in the United Arab Emirates |
title_short | The incidence of COVID-19 infection following emergency use authorization of BBIBP-CORV inactivated vaccine in frontline workers in the United Arab Emirates |
title_sort | incidence of covid-19 infection following emergency use authorization of bbibp-corv inactivated vaccine in frontline workers in the united arab emirates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752587/ https://www.ncbi.nlm.nih.gov/pubmed/35017530 http://dx.doi.org/10.1038/s41598-021-04244-1 |
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