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MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade

About 15–20% of breast cancer (BCa) is triple-negative BCa (TNBC), a devastating disease with limited therapeutic options. Aberrations in the PI3K/PTEN signaling pathway are common in TNBC. However, the therapeutic impact of PI3K inhibitors in TNBC has been limited and the mechanism(s) underlying th...

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Detalles Bibliográficos
Autores principales:	Wang, Wei, Han, Dong, Cai, Qinbo, Shen, Tao, Dong, Bingning, Lewis, Michael T., Wang, Runsheng, Meng, Yanling, Zhou, Wolong, Yi, Ping, Creighton, Chad J., Moore, David D., Yang, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752662/ https://www.ncbi.nlm.nih.gov/pubmed/35017531 http://dx.doi.org/10.1038/s41467-021-27921-1

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