SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability

Glioma stem cells (GSCs) contribute to the pathogenesis of glioblastoma, the most malignant form of glioma. The implication and underlying mechanisms of SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) on the GSC phenotypes remain unknown. We previously demonstrated that SMURF2 phosphorylation a...

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Detalles Bibliográficos
Autores principales: Hiraiwa, Manami, Fukasawa, Kazuya, Iezaki, Takashi, Sabit, Hemragul, Horie, Tetsuhiro, Tokumura, Kazuya, Iwahashi, Sayuki, Murata, Misato, Kobayashi, Masaki, Suzuki, Akane, Park, Gyujin, Kaneda, Katsuyuki, Todo, Tomoki, Hirao, Atsushi, Nakada, Mitsutoshi, Hinoi, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752672/
https://www.ncbi.nlm.nih.gov/pubmed/35017630
http://dx.doi.org/10.1038/s42003-021-02950-0

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