Cargando…

Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2

As the global burden of SARS-CoV-2 infections escalates, so does the evolution of viral variants with increased transmissibility and pathology. In addition to this entrenched diversity, RNA viruses can also display genetic diversity within single infected hosts with co-existing viral variants evolvi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gupta, Kapil, Toelzer, Christine, Williamson, Maia Kavanagh, Shoemark, Deborah K., Oliveira, A. Sofia F., Matthews, David A., Almuqrin, Abdulaziz, Staufer, Oskar, Yadav, Sathish K. N., Borucu, Ufuk, Garzoni, Frederic, Fitzgerald, Daniel, Spatz, Joachim, Mulholland, Adrian J., Davidson, Andrew D., Schaffitzel, Christiane, Berger, Imre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752678/ https://www.ncbi.nlm.nih.gov/pubmed/35017512 http://dx.doi.org/10.1038/s41467-021-27881-6

Ejemplares similares

Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein
por: Toelzer, Christine, et al.
Publicado: (2020)

The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron
por: Toelzer, Christine, et al.
Publicado: (2022)

Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy
por: Toelzer, Christine, et al.
Publicado: (2023)

SARS-CoV-2 spike variants differ in their allosteric responses to linoleic acid
por: Oliveira, A Sofia F, et al.
Publicado: (2023)

VLP‐factory™ and ADDomer(©): Self‐assembling Virus‐Like Particle (VLP) Technologies for Multiple Protein and Peptide Epitope Display
por: Sari‐Ak, Duygu, et al.
Publicado: (2021)

The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour
por: Sofia F. Oliveira, A., et al.
Publicado: (2021)

Molecular architecture of the autoinhibited kinesin-1 lambda particle
por: Weijman, Johannes F., et al.
Publicado: (2022)

Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation
por: Bufton, Joshua C, et al.
Publicado: (2022)

SARS-CoV-2 vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals low levels of viral backbone gene transcription alongside very high levels of SARS-CoV-2 S glycoprotein gene transcription
por: Almuqrin, Abdulaziz, et al.
Publicado: (2021)

Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA
por: Powers, Kyle T, et al.
Publicado: (2021)

MultiBac: Baculovirus-Mediated Multigene DNA Cargo Delivery in Insect and Mammalian Cells
por: Gupta, Kapil, et al.
Publicado: (2019)

Bottom-up assembly of viral replication cycles
por: Staufer, Oskar, et al.
Publicado: (2022)

Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein
por: Staufer, Oskar, et al.
Publicado: (2022)

The SARS-CoV-2 spike protein: balancing stability and infectivity
por: Berger, Imre, et al.
Publicado: (2020)

Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus
por: Aulicino, Francesco, et al.
Publicado: (2022)

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein
por: Davidson, Andrew D., et al.
Publicado: (2020)

Functional fusion of living systems with synthetic electrode interfaces
por: Staufer, Oskar, et al.
Publicado: (2016)

Adhesion Stabilized en Masse Intracellular Electrical Recordings from Multicellular Assemblies
por: Staufer, Oskar, et al.
Publicado: (2019)

Robots, pipelines, polyproteins: Enabling multiprotein expression in prokaryotic and eukaryotic cells
por: Vijayachandran, Lakshmi Sumitra, et al.
Publicado: (2011)

One-Pot Assembly of Complex Giant Unilamellar Vesicle-Based Synthetic Cells
por: Göpfrich, Kerstin, et al.
Publicado: (2019)

Vesicle Induced Receptor Sequestration: Mechanisms behind Extracellular Vesicle‐Based Protein Signaling
por: Staufer, Oskar, et al.
Publicado: (2022)

The MultiBac Baculovirus/Insect Cell Expression Vector System for Producing Complex Protein Biologics
por: Sari, Duygu, et al.
Publicado: (2015)

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome
por: Healy, Michael D., et al.
Publicado: (2023)

Bottom-up assembly of biomedical relevant fully synthetic extracellular vesicles
por: Staufer, Oskar, et al.
Publicado: (2021)

Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display
por: Vragniau, Charles, et al.
Publicado: (2019)

Nonsense-Mediated mRNA Decay Factor Functions in Human Health and Disease
por: Sun, Lingling, et al.
Publicado: (2023)

A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation
por: Deniaud, Aurélien, et al.
Publicado: (2015)

Nanopore ReCappable sequencing maps SARS-CoV-2 5′ capping sites and provides new insights into the structure of sgRNAs
por: Ugolini, Camilla, et al.
Publicado: (2022)

New insights into the interplay between the translation machinery and nonsense-mediated mRNA decay factors
por: Raimondeau, Etienne, et al.
Publicado: (2018)

No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors
por: Mailliot, Justine, et al.
Publicado: (2022)

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease
por: Avolio, Elisa, et al.
Publicado: (2021)

HIV-1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T cells
por: Hegedus, Andrea, et al.
Publicado: (2014)

In situ cryo-electron tomography reveals filamentous actin within the microtubule lumen
por: Paul, Danielle M., et al.
Publicado: (2020)

Efficient production of a mature and functional gamma secretase protease
por: Khan, Imran, et al.
Publicado: (2018)

Fetal Acrania (Exencephaly) in the Context of a Pregnant Female Taking Adalimumab for Psoriasis: A Case Report
por: Daham, Nujud, et al.
Publicado: (2020)

Polyproteins in structural biology
por: Crépin, Thibaut, et al.
Publicado: (2015)

An expandable, modular de novo protein platform for precision redox engineering
por: Hutchins, George H., et al.
Publicado: (2023)

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2
por: Clerici, Marcello, et al.
Publicado: (2014)

Cell Type Variability in the Incorporation of Lipids in the Dengue Virus Virion
por: Hitakarun, Atitaya, et al.
Publicado: (2022)

Current Treatment Options for Cystic Fibrosis-Related Liver Disease
por: Staufer, Katharina
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cqq947c9s1c0g26gdgs5cfn8fj