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Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer
The importance of integrating biomarkers into the TNM staging has been emphasized in the 8(th) Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional patholog...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752727/ https://www.ncbi.nlm.nih.gov/pubmed/35017545 http://dx.doi.org/10.1038/s41523-021-00362-1 |
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| author | Loi, Sherene Salgado, Roberto Adams, Sylvia Pruneri, Giancarlo Francis, Prudence A. Lacroix-Triki, Magali Joensuu, Heikki Dieci, Maria Vittoria Badve, Sunil Demaria, Sandra Gray, Robert Munzone, Elisabetta Drubay, Damien Lemonnier, Jerome Sotiriou, Christos Kellokumpu-Lehtinen, Pirkko Liisa Vingiani, Andrea Gray, Kathryn André, Fabrice Denkert, Carsten Piccart, Martine Roblin, Elvire Michiels, Stefan |
| author_facet | Loi, Sherene Salgado, Roberto Adams, Sylvia Pruneri, Giancarlo Francis, Prudence A. Lacroix-Triki, Magali Joensuu, Heikki Dieci, Maria Vittoria Badve, Sunil Demaria, Sandra Gray, Robert Munzone, Elisabetta Drubay, Damien Lemonnier, Jerome Sotiriou, Christos Kellokumpu-Lehtinen, Pirkko Liisa Vingiani, Andrea Gray, Kathryn André, Fabrice Denkert, Carsten Piccart, Martine Roblin, Elvire Michiels, Stefan |
| author_sort | Loi, Sherene |
| collection | PubMed |
| description | The importance of integrating biomarkers into the TNM staging has been emphasized in the 8(th) Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging in the Pathological and Clinical Prognostic Stage Groups from the AJJC 8(th) edition Cancer Staging System. This suggest that clinical and research studies on TNBC should take TILs into account in addition to stage, as for example patients with stage II TNBC and high TILs have a better outcome than patients with stage I and low TILs. |
| format | Online Article Text |
| id | pubmed-8752727 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-87527272022-01-20 Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer Loi, Sherene Salgado, Roberto Adams, Sylvia Pruneri, Giancarlo Francis, Prudence A. Lacroix-Triki, Magali Joensuu, Heikki Dieci, Maria Vittoria Badve, Sunil Demaria, Sandra Gray, Robert Munzone, Elisabetta Drubay, Damien Lemonnier, Jerome Sotiriou, Christos Kellokumpu-Lehtinen, Pirkko Liisa Vingiani, Andrea Gray, Kathryn André, Fabrice Denkert, Carsten Piccart, Martine Roblin, Elvire Michiels, Stefan NPJ Breast Cancer Brief Communication The importance of integrating biomarkers into the TNM staging has been emphasized in the 8(th) Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging in the Pathological and Clinical Prognostic Stage Groups from the AJJC 8(th) edition Cancer Staging System. This suggest that clinical and research studies on TNBC should take TILs into account in addition to stage, as for example patients with stage II TNBC and high TILs have a better outcome than patients with stage I and low TILs. Nature Publishing Group UK 2022-01-11 /pmc/articles/PMC8752727/ /pubmed/35017545 http://dx.doi.org/10.1038/s41523-021-00362-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Communication Loi, Sherene Salgado, Roberto Adams, Sylvia Pruneri, Giancarlo Francis, Prudence A. Lacroix-Triki, Magali Joensuu, Heikki Dieci, Maria Vittoria Badve, Sunil Demaria, Sandra Gray, Robert Munzone, Elisabetta Drubay, Damien Lemonnier, Jerome Sotiriou, Christos Kellokumpu-Lehtinen, Pirkko Liisa Vingiani, Andrea Gray, Kathryn André, Fabrice Denkert, Carsten Piccart, Martine Roblin, Elvire Michiels, Stefan Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer |
| title | Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer |
| title_full | Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer |
| title_fullStr | Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer |
| title_full_unstemmed | Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer |
| title_short | Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer |
| title_sort | tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752727/ https://www.ncbi.nlm.nih.gov/pubmed/35017545 http://dx.doi.org/10.1038/s41523-021-00362-1 |
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