IFNγ signaling integrity in colorectal cancer immunity and immunotherapy

The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of...

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Detalles Bibliográficos
Autores principales: Du, Wan, Frankel, Timothy L., Green, Michael, Zou, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752802/
https://www.ncbi.nlm.nih.gov/pubmed/34385592
http://dx.doi.org/10.1038/s41423-021-00735-3
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author Du, Wan
Frankel, Timothy L.
Green, Michael
Zou, Weiping
author_facet Du, Wan
Frankel, Timothy L.
Green, Michael
Zou, Weiping
author_sort Du, Wan
collection PubMed
description The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of the IFNγ signaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to ICB. Moreover, we discuss how to target IFNγ signaling to inform novel clinical trials to treat patients with colorectal cancer.
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spelling pubmed-87528022022-01-20 IFNγ signaling integrity in colorectal cancer immunity and immunotherapy Du, Wan Frankel, Timothy L. Green, Michael Zou, Weiping Cell Mol Immunol Review Article The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of the IFNγ signaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to ICB. Moreover, we discuss how to target IFNγ signaling to inform novel clinical trials to treat patients with colorectal cancer. Nature Publishing Group UK 2021-08-12 2022-01 /pmc/articles/PMC8752802/ /pubmed/34385592 http://dx.doi.org/10.1038/s41423-021-00735-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Du, Wan
Frankel, Timothy L.
Green, Michael
Zou, Weiping
IFNγ signaling integrity in colorectal cancer immunity and immunotherapy
title IFNγ signaling integrity in colorectal cancer immunity and immunotherapy
title_full IFNγ signaling integrity in colorectal cancer immunity and immunotherapy
title_fullStr IFNγ signaling integrity in colorectal cancer immunity and immunotherapy
title_full_unstemmed IFNγ signaling integrity in colorectal cancer immunity and immunotherapy
title_short IFNγ signaling integrity in colorectal cancer immunity and immunotherapy
title_sort ifnγ signaling integrity in colorectal cancer immunity and immunotherapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752802/
https://www.ncbi.nlm.nih.gov/pubmed/34385592
http://dx.doi.org/10.1038/s41423-021-00735-3
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