Glioma-targeted delivery of exosome-encapsulated antisense oligonucleotides using neural stem cells

Tropism of neural stem cells (NSCs) to hypoxic tumor areas provides an opportunity for the drug delivery. Here, we demonstrate that NSCs effectively transport antisense oligonucleotides (ASOs) targeting oncogenic and tolerogenic signal transducer and activator of transcription 3 (STAT3) protein into...

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Detalles Bibliográficos
Autores principales: Adamus, Tomasz, Hung, Chia-Yang, Yu, Chunsong, Kang, Elaine, Hammad, Mohamed, Flores, Linda, Nechaev, Sergey, Zhang, Qifang, Gonzaga, Joanna Marie, Muthaiyah, Kokilah, Swiderski, Piotr, Aboody, Karen S., Kortylewski, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752899/
https://www.ncbi.nlm.nih.gov/pubmed/35036069
http://dx.doi.org/10.1016/j.omtn.2021.12.029

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