Transposable element activation promotes neurodegeneration in a Drosophila model of Huntington's disease

Huntington's disease (HD) is an autosomal dominant disorder with progressive motor dysfunction and cognitive decline. The disease is caused by a CAG repeat expansion in the IT15 gene, which elongates a polyglutamine stretch of the HD protein, Huntingtin. No therapeutic treatments are available,...

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Detalles Bibliográficos
Autores principales: Casale, Assunta Maria, Liguori, Francesco, Ansaloni, Federico, Cappucci, Ugo, Finaurini, Sara, Spirito, Giovanni, Persichetti, Francesca, Sanges, Remo, Gustincich, Stefano, Piacentini, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752904/
https://www.ncbi.nlm.nih.gov/pubmed/35036881
http://dx.doi.org/10.1016/j.isci.2021.103702

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