The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis

Myelin oligodendrocyte-antibody-associated disease (MOGAD) often presents with severe optic neuritis (ON) but tends to recover better than in aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-NMOSD). We measured OCT and VEP in MOGAD and AQP4-NMOSD eyes with good visual function, with...

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Autores principales: Roca-Fernández, A, Camera, V, Loncarevic-Whitaker, G, Messina, S, Mariano, R, Vincent, A, Sharma, S, Leite, MI, Palace, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752955/
https://www.ncbi.nlm.nih.gov/pubmed/35035989
http://dx.doi.org/10.1177/20552173211066446
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author Roca-Fernández, A
Camera, V
Loncarevic-Whitaker, G
Messina, S
Mariano, R
Vincent, A
Sharma, S
Leite, MI
Palace, J
author_facet Roca-Fernández, A
Camera, V
Loncarevic-Whitaker, G
Messina, S
Mariano, R
Vincent, A
Sharma, S
Leite, MI
Palace, J
author_sort Roca-Fernández, A
collection PubMed
description Myelin oligodendrocyte-antibody-associated disease (MOGAD) often presents with severe optic neuritis (ON) but tends to recover better than in aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-NMOSD). We measured OCT and VEP in MOGAD and AQP4-NMOSD eyes with good visual function, with or without previous ON episodes. Surprisingly, OCT and/or VEPs were abnormal in 84% MOGAD-ON versus 38% AQP4-NMOSD-ON eyes (p = 0.009) with good vision, compared with 18% and 17% respectively of eyes with no previous ON. A sub-group with macular OCT performed as part of a research study confirmed both retinal and macular defects in visually-recovered MOGAD eyes. These findings have implications for investigation and management of MOGAD patients.
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spelling pubmed-87529552022-01-13 The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis Roca-Fernández, A Camera, V Loncarevic-Whitaker, G Messina, S Mariano, R Vincent, A Sharma, S Leite, MI Palace, J Mult Scler J Exp Transl Clin Brief Report Myelin oligodendrocyte-antibody-associated disease (MOGAD) often presents with severe optic neuritis (ON) but tends to recover better than in aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-NMOSD). We measured OCT and VEP in MOGAD and AQP4-NMOSD eyes with good visual function, with or without previous ON episodes. Surprisingly, OCT and/or VEPs were abnormal in 84% MOGAD-ON versus 38% AQP4-NMOSD-ON eyes (p = 0.009) with good vision, compared with 18% and 17% respectively of eyes with no previous ON. A sub-group with macular OCT performed as part of a research study confirmed both retinal and macular defects in visually-recovered MOGAD eyes. These findings have implications for investigation and management of MOGAD patients. SAGE Publications 2021-12-22 /pmc/articles/PMC8752955/ /pubmed/35035989 http://dx.doi.org/10.1177/20552173211066446 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Brief Report
Roca-Fernández, A
Camera, V
Loncarevic-Whitaker, G
Messina, S
Mariano, R
Vincent, A
Sharma, S
Leite, MI
Palace, J
The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis
title The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis
title_full The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis
title_fullStr The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis
title_full_unstemmed The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis
title_short The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis
title_sort use of oct in good visual acuity mogad and aqp4-nmosd patients; with and without optic neuritis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752955/
https://www.ncbi.nlm.nih.gov/pubmed/35035989
http://dx.doi.org/10.1177/20552173211066446
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