Extracellular cathepsin Z signals through the α(5) integrin and augments NLRP3 inflammasome activation

Respiratory silicosis is a preventable occupational disease that develops secondary to the aspiration of crystalline silicon dioxide (silica) into the lungs, activation of the NLRP3 inflammasome, and IL-1β production. Cathepsin Z has been associated with the development of inflammation and IL-1β pro...

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Detalles Bibliográficos
Autores principales: Campden, Rhiannon I., Warren, Amy L., Greene, Catherine J., Chiriboga, Jose A., Arnold, Corey R., Aggarwal, Devin, McKenna, Neil, Sandall, Christina F., MacDonald, Justin A., Yates, Robin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753182/
https://www.ncbi.nlm.nih.gov/pubmed/34864055
http://dx.doi.org/10.1016/j.jbc.2021.101459

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