Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL

Asparaginase therapy is a key component of chemotherapy for patients with T-cell acute lymphoblastic leukemia (T-ALL). Asparaginase depletes serum asparagine by deamination into aspartic acid. Normal hematopoietic cells can survive due to asparagine synthetase (ASNS) activity, whereas leukemia cells...

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Detalles Bibliográficos
Autores principales: Akahane, Koshi, Kimura, Shunsuke, Miyake, Kunio, Watanabe, Atsushi, Kagami, Keiko, Yoshimura, Kentaro, Shinohara, Tamao, Harama, Daisuke, Kasai, Shin, Goi, Kumiko, Kawai, Tomoko, Hata, Kenichiro, Kiyokawa, Nobutaka, Koh, Katsuyoshi, Imamura, Toshihiko, Horibe, Keizo, Look, A. Thomas, Minegishi, Masayoshi, Sugita, Kanji, Takita, Junko, Inukai, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753197/
https://www.ncbi.nlm.nih.gov/pubmed/34535013
http://dx.doi.org/10.1182/bloodadvances.2021004271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753197/
https://www.ncbi.nlm.nih.gov/pubmed/34535013
http://dx.doi.org/10.1182/bloodadvances.2021004271

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