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BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning

One of the most significant events during early embryonic development is the establishment of a basic embryonic body plan, which is defined by anteroposterior, dorsoventral (DV), and left-right axes. It is well-known that the morphogen gradient created by BMP signaling activity is crucial for DV axi...

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Autores principales: Yan, Yifang, Wang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753366/
https://www.ncbi.nlm.nih.gov/pubmed/35036406
http://dx.doi.org/10.3389/fcell.2021.799772
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author Yan, Yifang
Wang, Qiang
author_facet Yan, Yifang
Wang, Qiang
author_sort Yan, Yifang
collection PubMed
description One of the most significant events during early embryonic development is the establishment of a basic embryonic body plan, which is defined by anteroposterior, dorsoventral (DV), and left-right axes. It is well-known that the morphogen gradient created by BMP signaling activity is crucial for DV axis patterning across a diverse set of vertebrates. The regulation of BMP signaling during DV patterning has been strongly conserved across evolution. This is a remarkable regulatory and evolutionary feat, as the BMP gradient has been maintained despite the tremendous variation in embryonic size and shape across species. Interestingly, the embryonic DV axis exhibits robust stability, even in face of variations in BMP signaling. Multiple lines of genetic, molecular, and embryological evidence have suggested that numerous BMP signaling components and their attendant regulators act in concert to shape the developing DV axis. In this review, we summarize the current knowledge of the function and regulation of BMP signaling in DV patterning. Throughout, we focus specifically on popular model animals, such as Xenopus and zebrafish, highlighting the similarities and differences of the regulatory networks between species. We also review recent advances regarding the molecular nature of DV patterning, including the initiation of the DV axis, the formation of the BMP gradient, and the regulatory molecular mechanisms behind BMP signaling during the establishment of the DV axis. Collectively, this review will help clarify our current understanding of the molecular nature of DV axis formation.
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spelling pubmed-87533662022-01-13 BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning Yan, Yifang Wang, Qiang Front Cell Dev Biol Cell and Developmental Biology One of the most significant events during early embryonic development is the establishment of a basic embryonic body plan, which is defined by anteroposterior, dorsoventral (DV), and left-right axes. It is well-known that the morphogen gradient created by BMP signaling activity is crucial for DV axis patterning across a diverse set of vertebrates. The regulation of BMP signaling during DV patterning has been strongly conserved across evolution. This is a remarkable regulatory and evolutionary feat, as the BMP gradient has been maintained despite the tremendous variation in embryonic size and shape across species. Interestingly, the embryonic DV axis exhibits robust stability, even in face of variations in BMP signaling. Multiple lines of genetic, molecular, and embryological evidence have suggested that numerous BMP signaling components and their attendant regulators act in concert to shape the developing DV axis. In this review, we summarize the current knowledge of the function and regulation of BMP signaling in DV patterning. Throughout, we focus specifically on popular model animals, such as Xenopus and zebrafish, highlighting the similarities and differences of the regulatory networks between species. We also review recent advances regarding the molecular nature of DV patterning, including the initiation of the DV axis, the formation of the BMP gradient, and the regulatory molecular mechanisms behind BMP signaling during the establishment of the DV axis. Collectively, this review will help clarify our current understanding of the molecular nature of DV axis formation. Frontiers Media S.A. 2021-12-23 /pmc/articles/PMC8753366/ /pubmed/35036406 http://dx.doi.org/10.3389/fcell.2021.799772 Text en Copyright © 2021 Yan and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Yan, Yifang
Wang, Qiang
BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning
title BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning
title_full BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning
title_fullStr BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning
title_full_unstemmed BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning
title_short BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning
title_sort bmp signaling: lighting up the way for embryonic dorsoventral patterning
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753366/
https://www.ncbi.nlm.nih.gov/pubmed/35036406
http://dx.doi.org/10.3389/fcell.2021.799772
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