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Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium
Nowadays, the bone osseointegration in different environments is comparable, but the mechanism is unclear. This study aimed to investigate the osseointegration of different bioactive titanium surfaces under normoxic or high-altitude hypoxic environments. Titanium implants were subjected to one of tw...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753411/ https://www.ncbi.nlm.nih.gov/pubmed/35035356 http://dx.doi.org/10.3389/fphys.2021.689807 |
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author | Wang, Yarong Gan, Zekun Lu, Haibin Liu, Ziyi Shang, Peng Zhang, Jian Yin, Wuwei Chu, Hongxing Yuan, Renlei Ye, Yingxin Chen, Pei Rong, Mingdeng |
author_facet | Wang, Yarong Gan, Zekun Lu, Haibin Liu, Ziyi Shang, Peng Zhang, Jian Yin, Wuwei Chu, Hongxing Yuan, Renlei Ye, Yingxin Chen, Pei Rong, Mingdeng |
author_sort | Wang, Yarong |
collection | PubMed |
description | Nowadays, the bone osseointegration in different environments is comparable, but the mechanism is unclear. This study aimed to investigate the osseointegration of different bioactive titanium surfaces under normoxic or high-altitude hypoxic environments. Titanium implants were subjected to one of two surface treatments: (1) sanding, blasting, and acid etching to obtain a rough surface, or (2) extensive polishing to obtain a smooth surface. Changes in the morphology, proliferation, and protein expression of osteoblasts on the rough and smooth surfaces were examined, and bone formation was studied through western blotting and animal-based experiments. Our findings found that a hypoxic environment and rough titanium implant surface promoted the osteogenic differentiation of osteoblasts and activated the JAK1/STAT1/HIF-1α pathway in vitro. The animal study revealed that following implant insertion in tibia of rabbit, bone repair at high altitudes was slower than that at low altitudes (i.e., in plains) after 2weeks; however, bone formation did not differ significantly after 4weeks. The results of our study showed that: (1) The altitude hypoxia environment would affect the early osseointegration of titanium implants while titanium implants with rough surfaces can mitigate the effects of this hypoxic environment on osseointegration, (2) the mechanism may be related to the activation of JAK1/STAT1/HIF-1α pathway, and (3) our results suggest the osteogenesis of titanium implants, such as oral implants, is closely related to the oxygen environment. Clinical doctors, especially dentists, should pay attention to the influence of hypoxia on early osseointegration in patients with high altitude. For example, it is better to choose an implant system with rough implant surface in the oral cavity of patients with tooth loss at high altitude. |
format | Online Article Text |
id | pubmed-8753411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87534112022-01-13 Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium Wang, Yarong Gan, Zekun Lu, Haibin Liu, Ziyi Shang, Peng Zhang, Jian Yin, Wuwei Chu, Hongxing Yuan, Renlei Ye, Yingxin Chen, Pei Rong, Mingdeng Front Physiol Physiology Nowadays, the bone osseointegration in different environments is comparable, but the mechanism is unclear. This study aimed to investigate the osseointegration of different bioactive titanium surfaces under normoxic or high-altitude hypoxic environments. Titanium implants were subjected to one of two surface treatments: (1) sanding, blasting, and acid etching to obtain a rough surface, or (2) extensive polishing to obtain a smooth surface. Changes in the morphology, proliferation, and protein expression of osteoblasts on the rough and smooth surfaces were examined, and bone formation was studied through western blotting and animal-based experiments. Our findings found that a hypoxic environment and rough titanium implant surface promoted the osteogenic differentiation of osteoblasts and activated the JAK1/STAT1/HIF-1α pathway in vitro. The animal study revealed that following implant insertion in tibia of rabbit, bone repair at high altitudes was slower than that at low altitudes (i.e., in plains) after 2weeks; however, bone formation did not differ significantly after 4weeks. The results of our study showed that: (1) The altitude hypoxia environment would affect the early osseointegration of titanium implants while titanium implants with rough surfaces can mitigate the effects of this hypoxic environment on osseointegration, (2) the mechanism may be related to the activation of JAK1/STAT1/HIF-1α pathway, and (3) our results suggest the osteogenesis of titanium implants, such as oral implants, is closely related to the oxygen environment. Clinical doctors, especially dentists, should pay attention to the influence of hypoxia on early osseointegration in patients with high altitude. For example, it is better to choose an implant system with rough implant surface in the oral cavity of patients with tooth loss at high altitude. Frontiers Media S.A. 2021-11-18 /pmc/articles/PMC8753411/ /pubmed/35035356 http://dx.doi.org/10.3389/fphys.2021.689807 Text en Copyright © 2021 Wang, Gan, Lu, Liu, Shang, Zhang, Yin, Chu, Yuan, Ye, Chen and Rong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Wang, Yarong Gan, Zekun Lu, Haibin Liu, Ziyi Shang, Peng Zhang, Jian Yin, Wuwei Chu, Hongxing Yuan, Renlei Ye, Yingxin Chen, Pei Rong, Mingdeng Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium |
title | Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium |
title_full | Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium |
title_fullStr | Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium |
title_full_unstemmed | Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium |
title_short | Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium |
title_sort | impact of high-altitude hypoxia on early osseointegration with bioactive titanium |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753411/ https://www.ncbi.nlm.nih.gov/pubmed/35035356 http://dx.doi.org/10.3389/fphys.2021.689807 |
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