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Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models

BACKGROUND: Intratumoral viral oncolytic immunotherapy is a promising new approach for the treatment of a variety of solid cancers. CAN-2409 is a replication-deficient adenovirus that delivers herpes simplex virus thymidine kinase to cancer cells, resulting in local conversion of ganciclovir or vala...

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Detalles Bibliográficos
Autores principales:	Koch, Marilin S, Zdioruk, Mykola, Nowicki, Michal O, Griffith, Alec M, Aguilar, Estuardo, Aguilar, Laura K, Guzik, Brian W, Barone, Francesca, Tak, Paul P, Tabatabai, Ghazaleh, Lederer, James A, Chiocca, E Antonio, Lawler, Sean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753448/ https://www.ncbi.nlm.nih.gov/pubmed/35017150 http://dx.doi.org/10.1136/jitc-2021-003368

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