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Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study

This study aimed to describe the incidence of Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based retrospective cohort study of all episodes of SBSEC-bacteremia f...

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Autores principales: Öberg, Jonas, Rasmussen, Magnus, Buchwald, Pamela, Nilson, Bo, Inghammar, Malin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753481/
http://dx.doi.org/10.1017/S0950268821002533
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author Öberg, Jonas
Rasmussen, Magnus
Buchwald, Pamela
Nilson, Bo
Inghammar, Malin
author_facet Öberg, Jonas
Rasmussen, Magnus
Buchwald, Pamela
Nilson, Bo
Inghammar, Malin
author_sort Öberg, Jonas
collection PubMed
description This study aimed to describe the incidence of Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based retrospective cohort study of all episodes of SBSEC-bacteremia from 2003 to 2018 in Skåne Region, Sweden. Subspecies was determined by whole-genome sequencing. Medical charts were reviewed. The association between subspecies and CRC were analysed using logistic regression. In total 266 episodes of SBSEC-bacteremia were identified and the average annual incidence was 2.0 per 100 000 inhabitants. Of the 236 isolates available for typing, the most common subspecies was S. gallolyticus subsp. pasteurianus 88/236 (37%) followed by S. gallolyticus subsp. gallolyticus 58/236 (25%). In order to determine the risk of cancer following bacteremia, an incidence cohort of 174 episodes without a prior diagnosis of CRC or metastasised cancer was followed for 560 person-years. CRC was found in 13/174 (7%), of which 9 (69%) had S. gallolyticus subsp. gallolyticus-bacteremia. In contrast to other European studies, S. gallolyticus subsp. pasteurianus was the most common cause of SBSEC-bacteremia. CRC diagnosis after bacteremia was strongly associated with S. gallolyticus subsp. gallolyticus-bacteremia. Identification of SBSEC subspecies can guide clinical decision-making regarding CRC work-up following bacteremia.
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spelling pubmed-87534812022-01-27 Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study Öberg, Jonas Rasmussen, Magnus Buchwald, Pamela Nilson, Bo Inghammar, Malin Epidemiol Infect Original Paper This study aimed to describe the incidence of Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based retrospective cohort study of all episodes of SBSEC-bacteremia from 2003 to 2018 in Skåne Region, Sweden. Subspecies was determined by whole-genome sequencing. Medical charts were reviewed. The association between subspecies and CRC were analysed using logistic regression. In total 266 episodes of SBSEC-bacteremia were identified and the average annual incidence was 2.0 per 100 000 inhabitants. Of the 236 isolates available for typing, the most common subspecies was S. gallolyticus subsp. pasteurianus 88/236 (37%) followed by S. gallolyticus subsp. gallolyticus 58/236 (25%). In order to determine the risk of cancer following bacteremia, an incidence cohort of 174 episodes without a prior diagnosis of CRC or metastasised cancer was followed for 560 person-years. CRC was found in 13/174 (7%), of which 9 (69%) had S. gallolyticus subsp. gallolyticus-bacteremia. In contrast to other European studies, S. gallolyticus subsp. pasteurianus was the most common cause of SBSEC-bacteremia. CRC diagnosis after bacteremia was strongly associated with S. gallolyticus subsp. gallolyticus-bacteremia. Identification of SBSEC subspecies can guide clinical decision-making regarding CRC work-up following bacteremia. Cambridge University Press 2021-11-26 /pmc/articles/PMC8753481/ http://dx.doi.org/10.1017/S0950268821002533 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Original Paper
Öberg, Jonas
Rasmussen, Magnus
Buchwald, Pamela
Nilson, Bo
Inghammar, Malin
Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study
title Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study
title_full Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study
title_fullStr Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study
title_full_unstemmed Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study
title_short Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study
title_sort streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753481/
http://dx.doi.org/10.1017/S0950268821002533
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