Cargando…

The anti-tumor efficacy of 20(S)-protopanaxadiol, an active metabolite of ginseng, according to fasting on hepatocellular carcinoma

BACKGROUND: 20(S)-protopanaxadiol (20(S)-PPD), one of the main active metabolites of ginseng, performs a broad spectrum of anti-tumor effects. Our aims are to search out new strategies to enhance anti-tumor effects of natural products, including 20(S)-PPD. In recent years, fasting has been shown to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Wenzhen, Wang, Yifan, Zhou, Xinbo, Pan, Xiaohong, Lü, Junhong, Sun, Hongliu, Xie, Zeping, Chen, Shayan, Gao, Xue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753519/ https://www.ncbi.nlm.nih.gov/pubmed/35058733 http://dx.doi.org/10.1016/j.jgr.2021.06.002

Ejemplares similares

Ginseng saponin metabolite 20(S)-protopanaxadiol relieves pulmonary fibrosis by multiple-targets signaling pathways
por: Ren, Guoqing, et al.
Publicado: (2023)

Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways
por: GAO, JIAN-LI, et al.
Publicado: (2013)

Protopanaxadiol, an Active Ginseng Metabolite, Significantly Enhances the Effects of Fluorouracil on Colon Cancer
por: Wang, Chong-Zhi, et al.
Publicado: (2015)

Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK
por: Jin, Hong Ri, et al.
Publicado: (2019)

Protopanaxadiol manipulates gut microbiota to promote bone marrow hematopoiesis and enhance immunity in cyclophosphamide‐induced immunosuppression mice
por: Cao, Yuru, et al.
Publicado: (2023)

Effect of Ginseng Sapogenin Protopanaxadiol-Enriched Rice (DJ-PPD) on Immunomodulation
por: Monmai, Chaiwat, et al.
Publicado: (2023)

Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites
por: Chen, Xiao-Jia, et al.
Publicado: (2016)

Identification of candidate UDP-glycosyltransferases involved in protopanaxadiol-type ginsenoside biosynthesis in Panax ginseng
por: Kang, Kyo Bin, et al.
Publicado: (2018)

Synergistic production of 20(S)-protopanaxadiol from protopanaxadiol-type ginsenosides by β-glycosidases from Dictyoglomus turgidum and Caldicellulosiruptor bescii
por: Choi, Ji-Hyeon, et al.
Publicado: (2017)

20(S)-Protopanaxadiol saponins inhibit SKOV3 cell migration
por: LI, BIN, et al.
Publicado: (2016)

Computational and experimental characterization of estrogenic activities of 20(S, R)-protopanaxadiol and 20(S, R)-protopanaxatriol
por: Zhang, Tiehua, et al.
Publicado: (2020)

Polycaprolactone nanofibres loaded with 20(S)-protopanaxadiol for in vitro and in vivo anti-tumour activity study
por: Liu, Dan-qing, et al.
Publicado: (2018)

20(S)-Protopanaxadiol Inhibition of Progression and Growth of Castration-Resistant Prostate Cancer
por: Cao, Bo, et al.
Publicado: (2014)

Metabolite Profiling to Evaluate Metabolic Changes in Genetically Modified Protopanaxadiol-Enriched Rice
por: Sim, Ji-Eun, et al.
Publicado: (2023)

Characterization, Molecular Docking, and In Vitro Dissolution Studies of Solid Dispersions of 20(S)-Protopanaxadiol
por: Zhang, Qi, et al.
Publicado: (2017)

Enhanced Absorption Study of Ginsenoside Compound K (20-O-β-(D-Glucopyranosyl)-20(S)-protopanaxadiol) after Oral Administration of Fermented Red Ginseng Extract (HYFRG™) in Healthy Korean Volunteers and Rats
por: Choi, Il-Dong, et al.
Publicado: (2016)

Protopanaxadiol inhibits epithelial–mesenchymal transition of hepatocellular carcinoma by targeting STAT3 pathway
por: Yang, Lan, et al.
Publicado: (2019)

Beneficial effects of 20(S)-protopanaxadiol on antitumor activity and toxicity of cyclophosphamide in tumor-bearing mice
por: LIN, GUANGZHU, et al.
Publicado: (2013)

Modification of ginsenoside saponin composition via the CRISPR/Cas9-mediated knockout of protopanaxadiol 6-hydroxylase gene in Panax ginseng
por: Choi, Han Suk, et al.
Publicado: (2022)

Biotransformation of Protopanaxadiol-Type Ginsenosides in Korean Ginseng Extract into Food-Available Compound K by an Extracellular Enzyme from Aspergillus niger
por: Jeong, Eun-Bi, et al.
Publicado: (2020)

Platelet Protease Activated Receptor 1 Is Involved in the Hemostatic Effect of 20(S)-Protopanaxadiol by Regulating Calcium Signaling
por: Zhang, He, et al.
Publicado: (2020)

20(S)-Protopanaxadiol Saponins Mainly Contribute to the Anti-Atherogenic Effects of Panax notoginseng in ApoE Deficient Mice
por: Liu, Conghui, et al.
Publicado: (2019)

Ginsenoside metabolite 20(S)-protopanaxadiol promotes neural stem cell transition from a state of proliferation to differentiation by inducing autophagy and cell cycle arrest
por: Chen, Shali, et al.
Publicado: (2020)

Neuroprotective effects of 20(S)-protopanaxadiol against glutamate-induced mitochondrial dysfunction in PC12 cells
por: BAK, DONG-HO, et al.
Publicado: (2016)

20(S)-Protopanaxadiol Phospholipid Complex: Process Optimization, Characterization, In Vitro Dissolution and Molecular Docking Studies
por: Pu, Yiqiong, et al.
Publicado: (2016)

20(S)-Protopanaxadiol Inhibits Angiotensin II-Induced Epithelial- Mesenchymal Transition by Downregulating SIRT1
por: Wang, Yuchen, et al.
Publicado: (2019)

Formulation And Evaluation Of Nanostructured Lipid Carriers (NLCs) Of 20(S)-Protopanaxadiol (PPD) By Box-Behnken Design
por: Kim, Min-Hwan, et al.
Publicado: (2019)

Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis
por: Jo, Hantae, et al.
Publicado: (2021)

Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: Implications for the treatment of cognitive dysfunction
por: Chen, Feiyan, et al.
Publicado: (2023)

20-O-β-d-Xylopyranosyl(1→6)-β-d-glucopyranosyl-20(S)-protopanaxadiol methanol solvate
por: Li, Xing-Wei, et al.
Publicado: (2007)

20S-Protopanaxadiol, an aglycosylated ginsenoside metabolite, induces hepatic stellate cell apoptosis through liver kinase B1–AMP-activated protein kinase activation
por: Park, Sang Mi, et al.
Publicado: (2017)

Tentative identification of 20(S)-protopanaxadiol metabolites in human plasma and urine using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry
por: Ling, Jin, et al.
Publicado: (2019)

Alteration of Panax ginseng saponin composition by overexpression and RNA interference of the protopanaxadiol 6-hydroxylase gene (CYP716A53v2)
por: Park, Seong-Bum, et al.
Publicado: (2016)

20(S)-protopanaxadiol regio-selectively targets androgen receptor: anticancer effects in castration-resistant prostate tumors
por: Ben-Eltriki, Mohamed, et al.
Publicado: (2018)

Molecular Insight into Stereoselective ADME Characteristics of C20-24 Epimeric Epoxides of Protopanaxadiol by Docking Analysis
por: Guo, Wenna, et al.
Publicado: (2020)

A 20(S)-protopanaxadiol derivative PPD12 reverses ABCB1-mediated multidrug resistance with oral bioavailability and low toxicity
por: Wei, Shunfeng, et al.
Publicado: (2018)

A randomized, double-blind, placebo-controlled pilot study to assess the effects of protopanaxadiol saponin–enriched ginseng extract and pectinase-processed ginseng extract on the prevention of acute respiratory illness in healthy people
por: Hwang, Jeong-Hwan, et al.
Publicado: (2020)

Anti-Tumor Effects of Ginsenoside 20(S)-Protopanaxadiol and 1,25-Dihydroxyvitamin D3 Combination in Castration Resistant Prostate Cancer
por: Ben-Eltriki, Mohamed, et al.
Publicado: (2021)

Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions
por: Yang, Yanyan, et al.
Publicado: (2014)

Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng
por: Kim, Jeon-Kyung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2qndr0d0im2m3okldv6epql7uq