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Knockout of caspase-7 gene improves the expression of recombinant protein in CHO cell line through the cell cycle arrest in G2/M phase

BACKGROUND: Chinese hamster ovary cell line has been used routinely as a bioproduction factory of numerous biopharmaceuticals. So far, various engineering strategies have been recruited to improve the production efficiency of this cell line such as apoptosis engineering. Previously, it is reported t...

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Detalles Bibliográficos
Autores principales:	Safari, Fatemeh, Akbari, Bahman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753818/ https://www.ncbi.nlm.nih.gov/pubmed/35016732 http://dx.doi.org/10.1186/s40659-021-00369-9

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