Unraveling the molecular mechanisms of hyperlipidemia using integrated lncRNA and mRNA microarray data

Long non-coding RNAs (lncRNAs) have key roles in various diseases; however, their functions in hyperlipidemia (HLP) have remained elusive. In the present study, microarray technology was utilized to analyze the differential expression of lncRNAs and mRNAs in liver tissues of apolipoprotein E(-/-) mi...

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Detalles Bibliográficos
Autores principales: Xu, Bianling, Wang, Nan, Xu, Xuegong, Cai, Yongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753963/
https://www.ncbi.nlm.nih.gov/pubmed/35069841
http://dx.doi.org/10.3892/etm.2021.11083
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author Xu, Bianling
Wang, Nan
Xu, Xuegong
Cai, Yongmin
author_facet Xu, Bianling
Wang, Nan
Xu, Xuegong
Cai, Yongmin
author_sort Xu, Bianling
collection PubMed
description Long non-coding RNAs (lncRNAs) have key roles in various diseases; however, their functions in hyperlipidemia (HLP) have remained elusive. In the present study, microarray technology was utilized to analyze the differential expression of lncRNAs and mRNAs in liver tissues of apolipoprotein E(-/-) mice as a model of HLP compared with control mice. A total of 104 and 96 differentially expressed lncRNAs and mRNAs, respectively, were identified. Differentially expressed genes were significantly enriched in biological processes such as nitric oxide biosynthesis, innate immune response and inflammatory response. Finally, two pairs of target genes and 38 transcription factors with regulatory functions in HLP were predicted based on the lncRNA and mRNA co-expression network. The lncRNA expression profile was significantly altered in liver tissues of the mouse model of HLP and may provide novel targets for research into treatments.
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spelling pubmed-87539632022-01-21 Unraveling the molecular mechanisms of hyperlipidemia using integrated lncRNA and mRNA microarray data Xu, Bianling Wang, Nan Xu, Xuegong Cai, Yongmin Exp Ther Med Articles Long non-coding RNAs (lncRNAs) have key roles in various diseases; however, their functions in hyperlipidemia (HLP) have remained elusive. In the present study, microarray technology was utilized to analyze the differential expression of lncRNAs and mRNAs in liver tissues of apolipoprotein E(-/-) mice as a model of HLP compared with control mice. A total of 104 and 96 differentially expressed lncRNAs and mRNAs, respectively, were identified. Differentially expressed genes were significantly enriched in biological processes such as nitric oxide biosynthesis, innate immune response and inflammatory response. Finally, two pairs of target genes and 38 transcription factors with regulatory functions in HLP were predicted based on the lncRNA and mRNA co-expression network. The lncRNA expression profile was significantly altered in liver tissues of the mouse model of HLP and may provide novel targets for research into treatments. D.A. Spandidos 2022-02 2021-12-20 /pmc/articles/PMC8753963/ /pubmed/35069841 http://dx.doi.org/10.3892/etm.2021.11083 Text en Copyright: © Xu et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Xu, Bianling
Wang, Nan
Xu, Xuegong
Cai, Yongmin
Unraveling the molecular mechanisms of hyperlipidemia using integrated lncRNA and mRNA microarray data
title Unraveling the molecular mechanisms of hyperlipidemia using integrated lncRNA and mRNA microarray data
title_full Unraveling the molecular mechanisms of hyperlipidemia using integrated lncRNA and mRNA microarray data
title_fullStr Unraveling the molecular mechanisms of hyperlipidemia using integrated lncRNA and mRNA microarray data
title_full_unstemmed Unraveling the molecular mechanisms of hyperlipidemia using integrated lncRNA and mRNA microarray data
title_short Unraveling the molecular mechanisms of hyperlipidemia using integrated lncRNA and mRNA microarray data
title_sort unraveling the molecular mechanisms of hyperlipidemia using integrated lncrna and mrna microarray data
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753963/
https://www.ncbi.nlm.nih.gov/pubmed/35069841
http://dx.doi.org/10.3892/etm.2021.11083
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AT xuxuegong unravelingthemolecularmechanismsofhyperlipidemiausingintegratedlncrnaandmrnamicroarraydata
AT caiyongmin unravelingthemolecularmechanismsofhyperlipidemiausingintegratedlncrnaandmrnamicroarraydata

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