Cargando…

Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA‐DRB1 Genotype Associations and Immunological and Clinical Manifestations

OBJECTIVE: The heterogeneity of systemic lupus erythematosus (SLE) constitutes clinical and therapeutical challenges. We therefore studied whether unrecognized disease subgroups can be identified by using autoantibody profiling together with HLA‐DRB1 alleles and immunological and clinical data. METH...

Descripción completa

Detalles Bibliográficos
Autores principales:	Diaz‐Gallo, Lina‐Marcela, Oke, Vilija, Lundström, Emeli, Elvin, Kerstin, Ling Wu, Yee, Eketjäll, Susanna, Zickert, Agneta, Gustafsson, Johanna T., Jönsen, Andreas, Leonard, Dag, Birmingham, Daniel J., Nordmark, Gunnel, Bengtsson, Anders A., Rönnblom, Lars, Gunnarsson, Iva, Yu, Chack‐Yung, Padyukov, Leonid, Svenungsson, Elisabet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754019/ https://www.ncbi.nlm.nih.gov/pubmed/34658170 http://dx.doi.org/10.1002/acr2.11343

Ejemplares similares

High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus
por: Oke, Vilija, et al.
Publicado: (2019)

TNF-α and plasma albumin as biomarkers of disease activity in systemic lupus erythematosus
por: Idborg, Helena, et al.
Publicado: (2018)

IFN-λ1 with Th17 axis cytokines and IFN-α define different subsets in systemic lupus erythematosus (SLE)
por: Oke, Vilija, et al.
Publicado: (2017)

Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis
por: Bolin, Karin, et al.
Publicado: (2013)

Interferon (IFN)-λ is a potential mediator in lupus nephritis
por: Zickert, Agneta, et al.
Publicado: (2016)

Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus
por: Jönsen, Andreas, et al.
Publicado: (2011)

Anti-phosphatidylserine/prothrombin antibodies and thrombosis associate positively with HLA-DRB1*13 and negatively with HLA-DRB1*03 in SLE
por: Elbagir, Sahwa, et al.
Publicado: (2022)

Interleukin (IL) 16: a candidate urinary biomarker for proliferative lupus nephritis
por: Häyry, Aliisa, et al.
Publicado: (2022)

Histological antiphospholipid-associated nephropathy versus lupus nephritis in patients with systemic lupus erythematosus: an observational cross-sectional study with longitudinal follow-up
por: Gerhardsson, Jakob, et al.
Publicado: (2015)

Sex differences in clinical presentation of systemic lupus erythematosus
por: Ramírez Sepúlveda, Jorge I., et al.
Publicado: (2019)

DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus
por: Imgenberg-Kreuz, Juliana, et al.
Publicado: (2018)

Novel risk genes for systemic lupus erythematosus predicted by random forest classification
por: Almlöf, Jonas Carlsson, et al.
Publicado: (2017)

Urinary aberrations in systemic lupus erythematosus not always indicative of lupus nephritis: a cross-sectional cohort study
por: Karlsson, Linnea, et al.
Publicado: (2023)

Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations
por: Mobarrez, Fariborz, et al.
Publicado: (2016)

Myocardial infarctions, subtypes and coronary atherosclerosis in SLE: a case–control study
por: Samuelsson, Isak, et al.
Publicado: (2021)

Evaluation of B lymphocyte stimulator and a proliferation inducing ligand as candidate biomarkers in lupus nephritis based on clinical and histopathological outcome following induction therapy
por: Parodis, Ioannis, et al.
Publicado: (2015)

Antiphospholipid Antibodies in Lupus Nephritis
por: Parodis, Ioannis, et al.
Publicado: (2016)

Autoantibody and Cytokine Profiles during Treatment with Belimumab in Patients with Systemic Lupus Erythematosus
por: Parodis, Ioannis, et al.
Publicado: (2020)

Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
por: Torell, Agnes, et al.
Publicado: (2023)

Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis
por: Leonard, Dag, et al.
Publicado: (2018)

Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
por: Almlöf, Jonas Carlsson, et al.
Publicado: (2019)

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations
por: Wang, Chuan, et al.
Publicado: (2013)

Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome
por: Lundtoft, Christian, et al.
Publicado: (2022)

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5
por: Sigurdsson, Snaevar, et al.
Publicado: (2008)

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE
por: Sandling, Johanna K, et al.
Publicado: (2011)

Toll-like receptors revisited; a possible role for TLR1 in lupus nephritis
por: Yavuz, Sule, et al.
Publicado: (2021)

Contributions of de novo variants to systemic lupus erythematosus
por: Almlöf, Jonas Carlsson, et al.
Publicado: (2020)

Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity
por: Svenungsson, Elisabet, et al.
Publicado: (2021)

Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus
por: Sohrabian, Azita, et al.
Publicado: (2019)

Variants in BANK1 are associated with lupus nephritis of European ancestry
por: Bolin, Karin, et al.
Publicado: (2021)

Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis
por: Sjöwall, Christopher, et al.
Publicado: (2009)

Risk factors for cardiovascular mortality in patients with systemic lupus erythematosus, a prospective cohort study
por: Gustafsson, Johanna T, et al.
Publicado: (2012)

De novo lupus nephritis during treatment with belimumab
por: Parodis, Ioannis, et al.
Publicado: (2020)

Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus
por: Reid, Sarah, et al.
Publicado: (2021)

Case definitions in Swedish register data to identify systemic lupus erythematosus
por: Arkema, Elizabeth V, et al.
Publicado: (2016)

Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
por: Lundtoft, Christian, et al.
Publicado: (2022)

Excess atherosclerosis in systemic lupus erythematosus,—A matter of renal involvement: Case control study of 281 SLE patients and 281 individually matched population controls
por: Gustafsson, Johanna T., et al.
Publicado: (2017)

High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
por: Reid, Sarah, et al.
Publicado: (2020)

ALCAM and VCAM-1 as urine biomarkers of activity and long-term renal outcome in systemic lupus erythematosus
por: Parodis, Ioannis, et al.
Publicado: (2020)

Kynurenine pathway is altered in patients with SLE and associated with severe fatigue
por: Åkesson, Karolina, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vrv4ohmt6nc10hq500evlgau1d