Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible Relevance to Cancer and the Lytic Cycle of Kaposi’s Sarcoma-Associated Herpesvirus

The open reading frame 50 (ORF50) protein of Kaposi’s sarcoma-associated herpesvirus (KSHV) is the master regulator essential for initiating the viral lytic cycle. Previously, we have demonstrated that the ORF50 protein can cooperate with Sp3 to synergistically activate a set of viral and cellular g...

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Detalles Bibliográficos
Autores principales: Chen, Li-Yu, Chen, Lee-Wen, Hung, Chien-Hui, Lin, Chun-Liang, Wang, Shie-Shan, Chang, Pey-Jium
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754129/
https://www.ncbi.nlm.nih.gov/pubmed/35019687
http://dx.doi.org/10.1128/spectrum.01464-21

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